Document Detail

Evolutionarily conserved regulation of TOR signaling.
MedLine Citation:
PMID:  23698095     Owner:  NLM     Status:  Publisher    
The target of rapamycin (TOR) is an evolutionarily conserved protein kinase that regulates cell growth in response to various environmental as well as intracellular cues through the formation of two distinct TOR complexes (TORC), TORC1 and TORC2. Dysregulation of TORC1 and TORC2 activity is closely associated with various diseases, including diabetes, cancer, and neurodegenerative disorders. Over the past few years, new regulatory mechanisms of TORC1 and TORC2 activity have been elucidated. Furthermore, recent advances in the study of TOR inhibitors have revealed previously unrecognized cellular functions of TORC1. In this review, we briefly summarize the current understanding of the evolutionarily conserved TOR signaling from upstream regulators to downstream events.
Terunao Takahara; Tatsuya Maeda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-21
Journal Detail:
Title:  Journal of biochemistry     Volume:  -     ISSN:  1756-2651     ISO Abbreviation:  J. Biochem.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376600     Medline TA:  J Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Molecular and Cellular Biosciences, The University of Tokyo.
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