| Evolutionarily conserved orthologous families in phages are relatively rare in their prokaryotic hosts. | |
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MedLine Citation:
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PMID: 21317336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have identified conserved orthologs in completely sequenced genomes of double-strand DNA phages and arranged them into evolutionary families (phage orthologous groups [POGs]). Using this resource to analyze the collection of known phage genomes, we find that most orthologs are unique in their genomes (having no diverged duplicates [paralogs]), and while many proteins contain multiple domains, the evolutionary recombination of these domains does not appear to be a major factor in evolution of these orthologous families. The number of POGs has been rapidly increasing over the past decade, the percentage of genes in phage genomes that have orthologs in other phages has also been increasing, and the percentage of unknown "ORFans" is decreasing as more proteins find homologs and establish a family. Other properties of phage genomes have remained relatively stable over time, most notably the high fraction of genes that are never or only rarely observed in their cellular hosts. This suggests that despite the renowned ability of phages to transduce cellular genes, these cellular "hitchhiker" genes do not dominate the phage genomic landscape, and a large fraction of the genes in phage genomes maintain an evolutionary trajectory that is distinct from that of the host genes. |
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Authors:
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David M Kristensen; Xixu Cai; Arcady Mushegian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-02-11 |
Journal Detail:
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Title: Journal of bacteriology Volume: 193 ISSN: 1098-5530 ISO Abbreviation: J. Bacteriol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-08 Completed Date: 2011-06-06 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: United States |
Other Details:
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Languages: eng Pagination: 1806-14 Citation Subset: IM |
Affiliation:
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Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA. David.Kristensen@nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
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virology* Bacteriophages / classification*, genetics* Cluster Analysis Evolution, Molecular Phylogeny* Protein Structure, Tertiary Recombination, Genetic Transduction, Genetic Viral Proteins / genetics |
| Chemical | |
Reg. No./Substance:
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0/Viral Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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