Document Detail

Evolution of the vertebrate cardio-pulmonary system.
MedLine Citation:
PMID:  10099702     Owner:  NLM     Status:  MEDLINE    
Vertebrate lungs have long been thought to have evolved in fishes largely as an adaptation for life in hypoxic water. This view overlooks the possibility that lungs may have functioned to supply the heart with oxygen and may continue to serve this function in extant fishes. The myocardium of most vertebrates is avascular and obtains oxygen from luminal blood. Because oxygen-rich pulmonary blood mixes with oxygen-poor systemic blood before entering the heart of air-breathing fishes, lung ventilation may supply the myocardium with oxygen and expand aerobic exercise capabilities. Although sustained exercise in tetrapods is facilitated by septation of the heart and the formation of a dual pressure system, a divided cardio-pulmonary system may conflict with myocardial oxygenation because the right side of the heart is isolated from pulmonary oxygen. This may have contributed to the evolution of the coronary circulation.
C G Farmer
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of physiology     Volume:  61     ISSN:  0066-4278     ISO Abbreviation:  Annu. Rev. Physiol.     Publication Date:  1999  
Date Detail:
Created Date:  1999-05-26     Completed Date:  1999-05-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370600     Medline TA:  Annu Rev Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-92     Citation Subset:  IM    
Department of Ecology and Evolutionary Biology, University of California at Irvine 92697, USA.
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MeSH Terms
Cardiovascular Physiological Phenomena*
Lung / physiology*
Vertebrates / physiology*
Grant Support
1F32-HL09796-01/HL/NHLBI NIH HHS

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