Document Detail


Evolution of vertebrate appendicular structures: Insight from genetic and palaeontological data.
MedLine Citation:
PMID:  21337665     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The new body of evidence from fossils and comparative-developmental analysis of subset of appendicular patterning genes has revealed that limb elements seen in tetrapods are assembled in fish fin over evolutionary time. However, despite of deep homology in basic structure and underlying developmental system, there remains a large morphological gap between distal elements of tetrapod limb and distal fin skeleton of tetrapodomorph fish. Understanding the genetic basis of major transformations in distal-limb morphology is the next challenge for evolutionary developmental biologists. Here by integrating data from fossils, comparative-developmental and genetic studies, models are proposed describing the evolution of cis-regulatory elements as a basis for diversification of appendicular architecture. Instead of emphasizing the subset of developmental genes, for instance Hoxd genes, the focus here is on the significance of elucidating cis-regulatory elements for multiple other key molecular players of limb/fin development and genetic/molecular interactions among them, for a better understanding of the developmental and genetic basis of limb evolution. Developmental Dynamics, 2011. © 2011 Wiley-Liss, Inc.
Authors:
Amir Ali Abbasi
Related Documents :
21360545 - Association of il28b variants with response to pegylated-interferon alpha plus ribaviri...
16287045 - Prion genotypes in central america suggest selection for the v129 allele.
21377705 - Colour-scent associations in a tropical orchid: three colours but two odours.
20978265 - Association of genomic loci from a cardiovascular gene snp array with fibrinogen levels...
1265565 - Plasma cholinesterase variants - an unexpectedly high incidence of the silent allele.
18284565 - Patterns of differentiation in a colour polymorphism and in neutral markers reveal rapi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-18
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  -     ISSN:  1097-0177     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
National Center for Bioinformatics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. abbasiam@qau.edu.pk.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanisms of digit formation: Human malformation syndromes tell the story.
Next Document:  Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathw...