Document Detail


Evolution of thyroid 127I stores measured by X-ray fluorescence in subacute thyroiditis.
MedLine Citation:
PMID:  7054213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evaluation of the thyroid iodine content by x-ray fluorescence was performed in 13 patients throughout the course of subacute thyroiditis. In the initial hyperthyroid phase of the disease, the iodine stores of the thyroid were not completely depleted. The iodine content (6.5 +/- 3 mg) was about 2.5 times lower than normal values when thyroiditis had developed in a normal thyroid (10 patients); in 3 patients with goiter, it was elevated (29.6 +/- 6.7 mg) but was still within the normal range of euthyroid goitrous patients. After clinical remission, the iodine content of the gland increased only in two patients (+105% and +43% over the initial value, respectively). For the other patients, the iodine content decreased (from -5% to -100% of the initial value). Restoration of iodine stores occurred subsequently and appeared to be a slow and progressive phenomenon; in six patient, the iodine content was still below normal values 12 months after clinical remission (6.6 +/- 1.6 mg). These data suggest that the course of subacute thyroiditis might be longer than would appear from the clinical data, the hormonal assays, or the radioactive thyroid uptake data.
Authors:
P Fragu; P Rougier; M Schlumberger; M Tubiana
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  54     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-03-13     Completed Date:  1982-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  162-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Adult
Aged
Female
Humans
Iodine / metabolism*
Kinetics
Male
Middle Aged
Thyroglobulin / blood
Thyroid Gland / metabolism,  radiography*
Thyroiditis / drug therapy,  metabolism,  radiography*
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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