| Evolution of temporal lobe hypoperfusion in transient global amnesia: a serial single photon emission computed tomography study. | |
| | |
MedLine Citation:
|
PMID: 11147408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Previous functional neuroimaging studies performed during transient global amnesia (TGA) have not answered the central question regarding the etiology of TGA, namely: whether the observed hypoperfusion in the mesial temporal lobe structures reflects a primarily ischemic process or whether it represents a secondary phenomenon resulting from locally decreased metabolism. The authors performed Tc 99-m-bicisate brain single photon-emission computed tomography (SPECT) scanning in a 66-year-old man during an episode of TGA, 24 hours after the episode and 3 months after the episode. To the authors' knowledge, this is the only reported study in which a follow-up SPECT scan was performed within 24 hours. The initial study showed bilateral mesial temporal lobe hypoperfusion that partially resolved after 24 hours and returned to normal at 3 months. Resolution of the SPECT scan abnormalities correlated well with resolution of the memory loss. These findings agree with previously reported SPECT, positron-emission tomography (PET), and diffusion magnetic resonance imaging (MRI) studies that indicate the mesial temporal lobe structures as the major site of pathology in TGA. The authors suggest that a process causing decreased local metabolism, such as cortical spreading depression, constitutes the primary pathophysiologic mechanism in this case. |
| | |
Authors:
|
T G Jovin; R A Vitti; L F McCluskey |
Related Documents
:
|
11801698 - Direct comparison of spatially normalized pet and spect scans in alzheimer's disease. 19801218 - Patterns, variants, artifacts, and pitfalls in conventional radionuclide bone imaging a... 12002708 - The effect of scatter correction on 123i-imp brain perfusion spet with the triple energ... 10691118 - Contralateral eeg slowing and amobarbital distribution in wada test: an intracarotid sp... 21242848 - Trochlear calcification mimicking an orbital foreign body. 2061498 - Experimental gd-dtpa polylysine enhanced mr angiography: sequence optimization. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 10 ISSN: 1051-2284 ISO Abbreviation: J Neuroimaging Publication Date: 2000 Oct |
Date Detail:
|
Created Date: 2000-11-09 Completed Date: 2000-12-14 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
|
Languages: eng Pagination: 238-41 Citation Subset: IM |
Affiliation:
|
Department of Neurology, University of Pennsylvania Health System, Pennsylvania Hospital, Philadelphia, PA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Amnesia, Transient Global / etiology*, physiopathology, radionuclide imaging Brain Ischemia / complications Cerebrovascular Disorders / complications*, radionuclide imaging Cortical Spreading Depression / physiology Cysteine / analogs & derivatives*, diagnostic use Follow-Up Studies Humans Magnetic Resonance Imaging Male Organotechnetium Compounds / diagnostic use Radiopharmaceuticals / diagnostic use Temporal Lobe / blood supply*, metabolism, radionuclide imaging Tomography, Emission-Computed, Single-Photon* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
|
0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m bicisate; 52-90-4/Cysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: False subarachnoid hemorrhage in anoxic encephalopathy with brain swelling.
Next Document: Reduction of carotid arterial blood flow in ventricular septal defect associated with severe congest...