| Evolution of rheological properties of erythrocytes and left ventricular geometry in cardiovascular disease risk patients. | |
| | |
MedLine Citation:
|
PMID: 20675895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The evolution of rheological properties of erythrocytes and geometrical parameters of left ventricle during therapies aimed at reducing cardiovascular disease (CVD) risk has been investigated. The study group consisted of 29 individuals who were diagnosed with the presence of at least one CVD risk factor at the time of entry to the study. Appropriate therapies were applied and the patients were followed for two years. Two groups of patients could be distinguished. The first group consisted of 12 individuals who were rigorously applying the therapy and for whom blood pressure, total cholesterol, LDL and glucose returned to normal levels. The second group included 17 patients for whom the above mentioned parameters remained pathological in spite of the applied therapy. In the first group, erythrocyte deformability as well as LVMI improved: deformability increased on average by 17% (p < 0.025), whereas LVMI decreased by 8% but not in a statistically significant manner (p < 0.27). In the second group, the results indicate worsening of both hemorheological properties and left ventricular geometry: RBC deformability became lower by 15% (p < 0.00001) and LVMI increased by 18% although this change was not statistically significant (p < 0.19). The results indicate that blood rheology improves when the CVD risk is reduced by administered therapy and worsens when the risk increases. Similar behavior shows LVMI. It is very likely that left ventricular geometry is influenced by blood rheology. |
| | |
Authors:
|
M Fornal; R A Korbut; J Królczyk; T Grodzicki |
Related Documents
:
|
8887015 - Therapeutic benefit of benfluorex in type ii diabetic patients treated with sulfonylureas. 20224285 - Treatment of alzheimer's disease with a cholinesterase inhibitor combined with antioxid... 16864965 - Statin use before by-pass surgery decreases the incidence and shortens the duration of ... 18572175 - Effect of statin therapy on coronary fibrous-cap thickness in patients with acute coron... 3102035 - Solitary plasmacytomas of bone and extramedullary plasmacytomas. a clinicopathologic an... 21080835 - Telemonitoring in patients with heart failure. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical hemorheology and microcirculation Volume: 45 ISSN: 1875-8622 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-08-02 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 155-9 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine and Gerontology, Collegium Medicum, Jagiellonian University, Krakow, Poland. Fornal@su.krakow.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cardiovascular Diseases
/
etiology Erythrocyte Deformability Erythrocytes / physiology* Follow-Up Studies Hemorheology* Humans Hypertrophy, Left Ventricular / therapy* Middle Aged Risk |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The different isoforms of the receptor for advanced glycation end products are modulated by pharmaco...
Next Document: The endothelial-protective effects of HMG-CoA reductase inhibition in the setting of ischemia and re...