Document Detail


Evolution of programmed cell fusion: common mechanisms and distinct functions.
MedLine Citation:
PMID:  20419783     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eukaryotic cells have evolved diverged mechanisms to merge cells. Here, we discuss three types of cell fusion: (1) Non-self-fusion, cells with different genetic contents fuse to start a new organism and fusion between enveloped viruses and host cells; (2) Self-fusion, genetically identical cells fuse to form a multinucleated cell; and (3) Auto-fusion, a single cell fuses with itself by bringing specialized cell membrane domains into contact and transforming itself into a ring-shaped cell. This is a new type of selfish fusion discovered in C. elegans. We divide cell fusion into three stages: (1) Specification of the cell-fusion fate; (2) Cell attraction, attachment, and recognition; (3) Execution of plasma membrane fusion, cytoplasmic mixing and cytoskeletal rearrangements. We analyze cell fusion in diverse biological systems in development and disease emphasizing the mechanistic contributions of C. elegans to the understanding of programmed cell fusion, a genetically encoded pathway to merge specific cells.
Authors:
Meital Oren-Suissa; Benjamin Podbilewicz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  239     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1515-28     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Wiley-Liss, Inc.
Affiliation:
Department of Biology, Technion, Israel Institute of Technology, Haifa, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans
Cell Adhesion
Cell Fusion*
Cell Lineage

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