| Evolution of pregnancies and initial follow-up of newborns delivered after intracytoplasmic sperm injection. | |
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MedLine Citation:
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PMID: 8968015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To analyze the in vivo development of embryos conceived after intracytoplasmic sperm injection (ICSI), as well as obstetric outcome, occurrence of chromosomal abnormalities, and rate of congenital malformations in neonates born as a result of this treatment. DESIGN: Retrospective study. SETTING: University-based in vitro fertilization (IVF) clinic. PATIENTS: A total of 751 couples in whom the male partners were presumed to be the cause of repeated failed IVF attempts or whose semen parameters were unacceptable for conventional IVF treatment. INTERVENTIONS: Analysis of pregnancies resulting from 987 ICSI cycles; pregnancy outcome data were obtained from the records of obstetrician-gynecologists and/or pediatricians. MAIN OUTCOME MEASURES: Pregnancy rates, obstetric outcome, and frequency of chromosomal abnormalities and congenital malformations. RESULTS: The overall clinical pregnancy (fetal heartbeat) rate was 44.3%, with a resultant delivery rate per ICSI cycle of 38.7% (n=382). In 8 of 11 miscarriages for which cytogenetic data were available, an autosomal trisomy was found, and 7 additional pregnancies were terminated because of a chromosomal abnormality after prenatal diagnosis. There was an equal distribution of vaginal vs cesarean deliveries (n=192 and n=190, respectively). Of the 578 neonates resulting from treatment by ICSI, 15 (2.6%) presented with congenital abnormalities (9 major and 6 minor abnormalities). However, this frequency of malformations is lower than that observed in offspring born after standard IVF at our institution. Furthermore, when pregnancy outcome of ICSI vs IVF was analyzed in terms of semen origin, no differences were found in the frequency of miscarriages or in the rate of congenital malformations. CONCLUSIONS: The evolution of pregnancies and occurrence of congenital malformations following treatment by ICSI were within the range observed with standard in vitro fertilization. |
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Authors:
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G D Palermo; L T Colombero; G L Schattman; O K Davis; Z Rosenwaks |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 276 ISSN: 0098-7484 ISO Abbreviation: JAMA Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-01-02 Completed Date: 1997-01-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1893-7 Citation Subset: AIM; IM |
Affiliation:
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Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, The New York Hospital-Cornell Medical Center, New York, NY 10021-4872, USA. gdpalerm@mail.med.cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromosome Aberrations Chromosome Disorders Congenital Abnormalities Female Fertilization in Vitro* / methods Humans Infant, Newborn Infertility, Male Male Microinjections Oocytes Pregnancy Pregnancy Outcome* Pregnancy Rate Retrospective Studies Spermatozoa |
| Comments/Corrections | |
Comment In:
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JAMA. 1997 Mar 26;277(12):963-4
[PMID:
9091665
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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