| Evolution of portal-systemic collateral vasopressin response in endotoxemic portal hypertensive rats. | |
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MedLine Citation:
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PMID: 19295490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cirrhotic patients with portal hypertension and variceal hemorrhage are vulnerable to endotoxemia. However, the direct influence of endotoxemia on portal-systemic collateral vasculature remains unexplored. In this study, portal hypertension was induced in Sprague-Dawley rats by partial portal vein ligation. On the 7th day after portal vein ligation, at 0.5, 1.5, and 5 h post endotoxin (LPS; Escherichia coli serotype O111:B4, 3 mg/kg, i.p., E0.5, E1.5 and E5, respectively) or saline (control, C0.5, C1.5, and C5, respectively) injection, hemodynamic measurements and concentration-response relationships to arginine vasopressin (AVP; 10(-10)-10(-7) mol/L) in collateral vascular bed were obtained. In another six parallel groups, reverse-transcriptase-polymerase chain reaction of iNOS, eNOS, and endothelin 1 (ET-1) mRNA expressions for splenorenal shunt, the most prominent intra-abdominal collateral vessel, was performed. The results showed that E0.5 had lower perfusion pressure changes to AVP and higher splenorenal shunt eNOS expression than C0.5 group (P < 0.05). Compared with C1.5, tachycardia, higher perfusion pressure changes and enhanced splenorenal shunt iNOS and ET-1 expression were observed in E1.5 group (P < 0.05). In E5, systemic and portal hypotension with markedly enhanced collateral AVP responsiveness and splenorenal shunt iNOS and ET-1 expressions were noted (P < 0.05). In conclusion, vasoactive substances counterregulation participates, at least in part, the time-dependent changes of collateral AVP responsiveness in endotoxemic portal hypertensive rats. |
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Authors:
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Hui-Chun Huang; Sun-Sang Wang; Ching-Chih Chang; Fa-Yauh Lee; Han-Chieh Lin; Ming-Chih Hou; Tzu-Hua Teng; Yi-Chou Chen; Shou-Dong Lee |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: 32 ISSN: 1540-0514 ISO Abbreviation: Shock Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-16 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: United States |
Other Details:
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Languages: eng Pagination: 503-8 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / pharmacology* Endothelin-1 / genetics Endotoxemia / physiopathology* Hemodynamics / drug effects Hypertension, Portal* Lipopolysaccharides / pharmacology* Male Nitric Oxide Synthase Type II / genetics Nitric Oxide Synthase Type III / genetics Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Vasoconstrictor Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Lipopolysaccharides; 0/Vasoconstrictor Agents; 113-79-1/Arginine Vasopressin; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III |
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