Document Detail


Evolution of portal-systemic collateral vasopressin response in endotoxemic portal hypertensive rats.
MedLine Citation:
PMID:  19295490     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cirrhotic patients with portal hypertension and variceal hemorrhage are vulnerable to endotoxemia. However, the direct influence of endotoxemia on portal-systemic collateral vasculature remains unexplored. In this study, portal hypertension was induced in Sprague-Dawley rats by partial portal vein ligation. On the 7th day after portal vein ligation, at 0.5, 1.5, and 5 h post endotoxin (LPS; Escherichia coli serotype O111:B4, 3 mg/kg, i.p., E0.5, E1.5 and E5, respectively) or saline (control, C0.5, C1.5, and C5, respectively) injection, hemodynamic measurements and concentration-response relationships to arginine vasopressin (AVP; 10(-10)-10(-7) mol/L) in collateral vascular bed were obtained. In another six parallel groups, reverse-transcriptase-polymerase chain reaction of iNOS, eNOS, and endothelin 1 (ET-1) mRNA expressions for splenorenal shunt, the most prominent intra-abdominal collateral vessel, was performed. The results showed that E0.5 had lower perfusion pressure changes to AVP and higher splenorenal shunt eNOS expression than C0.5 group (P < 0.05). Compared with C1.5, tachycardia, higher perfusion pressure changes and enhanced splenorenal shunt iNOS and ET-1 expression were observed in E1.5 group (P < 0.05). In E5, systemic and portal hypotension with markedly enhanced collateral AVP responsiveness and splenorenal shunt iNOS and ET-1 expressions were noted (P < 0.05). In conclusion, vasoactive substances counterregulation participates, at least in part, the time-dependent changes of collateral AVP responsiveness in endotoxemic portal hypertensive rats.
Authors:
Hui-Chun Huang; Sun-Sang Wang; Ching-Chih Chang; Fa-Yauh Lee; Han-Chieh Lin; Ming-Chih Hou; Tzu-Hua Teng; Yi-Chou Chen; Shou-Dong Lee
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  32     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine Vasopressin / pharmacology*
Endothelin-1 / genetics
Endotoxemia / physiopathology*
Hemodynamics / drug effects
Hypertension, Portal*
Lipopolysaccharides / pharmacology*
Male
Nitric Oxide Synthase Type II / genetics
Nitric Oxide Synthase Type III / genetics
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Vasoconstrictor Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Endothelin-1; 0/Lipopolysaccharides; 0/Vasoconstrictor Agents; 113-79-1/Arginine Vasopressin; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III

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