| Evolution and pathophysiology of chronic systolic heart failure. | |
| | |
MedLine Citation:
|
PMID: 11089706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Understanding of the pathophysiology of chronic systolic heart failure evolved from a purely mechanical model to one in which a cascade of neurohormones and biologically active molecules are thought to be critical in the development, maintenance, and progression of the disease. Two important neurohormonal systems are the sympathetic nervous and renin-angiotensin-aldosterone systems. Initially, increases in norepinephrine concentrations from the sympathetic nervous system and in angiotensin II and aldosterone are beneficial in the short term to maintain cardiac output after an insult to the myocardium. However, long-term exposure to these neurohormones causes alterations of myocytes and interstitial make-up of the heart. These alterations in myocardium lead to progression of heart failure and, eventually, death. |
| | |
Authors:
|
B E Bleske |
Related Documents
:
|
10760066 - 11beta-hydroxysteroid dehydrogenase in human vascular cells. 17685956 - Outcomes of laparoscopic adrenalectomy for hyperaldosteronism. 17048216 - Aldosterone-producing adenoma accompanied with renal artery stenosis. 16957426 - Ambulatory blood pressure monitoring in secondary arterial hypertension due to adrenal ... 6809996 - The dynamic response of the cardiopulmonary parameters to passive head-up tilt. 11818766 - Use of dynamic negative airway pressure (dnap) to assess sedative-induced upper airway ... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Pharmacotherapy Volume: 20 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2001-02-15 Completed Date: 2001-02-15 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 349S-358S Citation Subset: IM |
Affiliation:
|
University of Michigan College of Pharmacy, University of Michigan Health Systems, Ann Arbor 48109-1065, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiac Output, Low* / economics, mortality, physiopathology Chronic Disease Humans Renin-Angiotensin System / physiology* Sympathetic Nervous System / metabolism, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Radiology quality and performance metrics on the Web: a management information and communications to...
Next Document: beta-blocker therapy: a standard of care for heart failure.