Document Detail


Evolution of nacre: biochemistry and proteomics of the shell organic matrix of the cephalopod Nautilus macromphalus.
MedLine Citation:
PMID:  19472248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In mollusks, one of the most widely studied shell textures is nacre, the lustrous aragonitic layer that constitutes the internal components of the shells of several bivalves, a few gastropods,and one cephalopod: the nautilus. Nacre contains a minor organic fraction, which displays a wide range of functions in relation to the biomineralization process. Here, we have biochemically characterized the nacre matrix of the cephalopod Nautilus macromphalus. The acid-soluble matrix contains a mixture of polydisperse and discrete proteins and glycoproteins, which interact with the formation of calcite crystals. In addition, a few bind calcium ions. Furthermore, we have used a proteomic approach,which was applied to the acetic acid-soluble and -insoluble shell matrices, as well as to spots obtained after 2D gel electrophoresis. Our data demonstrate that the insoluble and soluble matrices, although different in their bulk monosaccharide and amino acid compositions, contain numerous shared peptides. Strikingly, most of the obtained partial sequences are entirely new. A few only partly match with bivalvian nacre proteins.Our findings have implications for knowledge of the long-term evolution of molluskan nacre matrices.
Authors:
Benjamin Marie; Frédéric Marin; Arul Marie; Laurent Bédouet; Lionel Dubost; Gérard Alcaraz; Christian Milet; Gilles Luquet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  10     ISSN:  1439-7633     ISO Abbreviation:  Chembiochem     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-17     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1495-506     Citation Subset:  IM    
Affiliation:
UMR CNRS 5561 Biogéosciences, Université de Bourgogne, 6 Bd Gabriel, 21000 Dijon, France. benjamin.marie@u-bourgogne.fr
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Calcium Carbonate / chemistry
Chromatography, High Pressure Liquid
Evolution*
Nautilus / chemistry*
Proteins / analysis*,  chemistry,  isolation & purification
Proteome / analysis*,  chemistry,  isolation & purification
Proteomics / methods*
Sequence Alignment
Solubility
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemical
Reg. No./Substance:
0/Proteins; 0/Proteome; 471-34-1/Calcium Carbonate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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