Document Detail


Evolution of the mitochondrial genetic code. I. Origin of AGR serine and stop codons in metazoan mitochondria.
MedLine Citation:
PMID:  2506356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AGA and AGG (AGR) are arginine codons in the universal genetic code. These codons are read as serine or are used as stop codons in metazoan mitochondria. The arginine residues coded by AGR in yeast or Trypanosoma are coded by arginine CGN throughout metazoan mitochondria. AGR serine sites in metazoan mitochondria are occupied mainly in corresponding sites in yeast or Trypanosoma mitochondria by UCN serine, AGY serine, or codons for amino acids other than serine or arginine. Based on these observations, we propose the following evolutionary events. AGR codons became unassigned because of deletion of tRNA Arg (UCU) and elimination of AGR codons by conversion to CGN arginine codons. Upon acquisition by serine tRNA of pairing ability with AGR codons, some codons for amino acids other than arginine mutated to AGR, and were captured by anticodon GCU in serine tRNA. During vertebrate mitochondrial evolution, AGR stop codons presumably were created from UAG stop by deletion of the first nucleotide U and by use of R as the third nucleotide that had existed next to the ancestral UAG stop.
Authors:
S Osawa; T Ohama; T H Jukes; K Watanabe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of molecular evolution     Volume:  29     ISSN:  0022-2844     ISO Abbreviation:  J. Mol. Evol.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-26     Completed Date:  1989-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0360051     Medline TA:  J Mol Evol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  202-7     Citation Subset:  IM; S    
Affiliation:
Nagoya University, Laboratory of Molecular Genetics, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticodon / genetics
Arginine
Base Sequence
Codon / genetics*
Evolution*
Genetic Code*
Humans
Invertebrates
Mitochondria / metabolism*
Molecular Sequence Data
RNA, Messenger / genetics*
RNA, Transfer / genetics
Serine*
Species Specificity
Vertebrates
Chemical
Reg. No./Substance:
0/Anticodon; 0/Codon; 0/RNA, Messenger; 56-45-1/Serine; 74-79-3/Arginine; 9014-25-9/RNA, Transfer

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