Document Detail


Evolution of the management of acquired neurogenic bladder in children using intradetrusor botulinum toxin type A injections: 5-year experience and perspectives.
MedLine Citation:
PMID:  22115699     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To report the clinical and urodynamic results of repeated intradetrusor botulinum toxin type A injections in children with an acquired neurogenic bladder. PATIENTS AND METHOD: We reviewed the data of 8 patients presenting an acquired neurogenic bladder treated between 2005 and 2010. Their mean age was 12.4 years old (range: 5-18). They were all on clean intermittent catheterization. All patients presented detrusor overactivity resistant to oral anticholinergic treatment. They received between 2 and 6 injections at a dose of 12 botulinum toxin units (BU)/kg (maximum 300 BU). Cystometry was performed 4-8 weeks after treatment. RESULTS: Five patients became completely dry, 2 were only rarely wet, and data are lacking for 1 patient. Febrile urinary tract infections ceased after 1 or 2 injections. The mean maximal detrusor pressure decreased below 40 cmH(2)O after 1, 2 and 3 injections. The normalized safe capacity rose significantly after 1, 2 and 3 injections. The normalized maximal bladder capacity rose similarly after 1, 2 and 3 injections although not always significantly. CONCLUSION: Intradetrusor botulinum toxin-A injections significantly reduce detrusor pressure and can be repeated with efficacy. They have their place in between anticholinergic treatment and surgery. The procedure could be simplified and the dosage reduced.
Authors:
R Le Nué; L Harper; M De Sèze; C Bouteiller; D Goossens; E Dobremez
Related Documents :
7441009 - Prospective, randomized comparative study of clindamycin, chloramphenicol, and ticarcil...
8169699 - Double-blind randomized prospective study of the efficacy of antibiotic prophylaxis for...
1322559 - Effect of piperacillin/tazobactam therapy on intestinal microflora.
1291309 - Clindamycin versus phenoxymethylpenicillin in the treatment of acute orofacial infections.
3276469 - Antimicrobial bowel preparation. oral, parenteral, or both?
18727929 - Therapy of metronidazole with azathioprine to prevent postoperative recurrence of crohn...
21130599 - Hydroxyapatite-coated femoral stem/porous-coated acetabulum survivorship at 15 years.
10665719 - Op-1 for cervical spine fusion: bridging bone in only 1 of 4 rheumatoid patients but pr...
24965149 - Outcome and complications after intra-arterial thrombolysis for lower limb ischaemia wi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-22
Journal Detail:
Title:  Journal of pediatric urology     Volume:  -     ISSN:  1873-4898     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233150     Medline TA:  J Pediatr Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Service de Chirurgie Pédiatrique, Hôpital des Enfants, CHU de Bordeaux, Place Amélie Raba Léon, 33 076 Bordeaux, France; University of Bordeaux, F-33000 Bordeaux, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Implementation of 24/7 radiology services in an academic medical centre level 1 trauma centre: Impac...
Next Document:  Lack of association between serum paraoxonase-1 activity and residual platelet aggregation during du...