Document Detail

Evolution of lymph thrombi in experimental Brugia malayi infections: a scanning electron microscopic study.
MedLine Citation:
PMID:  3561034     Owner:  NLM     Status:  MEDLINE    
Lymph thrombi in cats experimentally-infected with Brugia malayi were examined by scanning electron microscopy. A variety of morphological forms were noted and it appeared that thrombi undergo a maturation process characterized by at least three transitional phases. Initially, the thrombus consists of erythrocytes encased in fibrin (Phase I). Phase II thrombi are characterized by the appearance of phagocytic cells and fibroblasts on the surface of the thrombus. At the end of the maturation process, the thrombus surface consists solely of fibroblasts or endothelial cells, perhaps derived from the vessel wall (Phase III). Occlusion of the lymphatic lumen by thrombi and the accompanying inflammatory response triggered by B. malayi infection may be a major factor in the pathogenesis of lymph stasis in this disorder.
R C Fader; A Ewert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lymphology     Volume:  19     ISSN:  0024-7766     ISO Abbreviation:  Lymphology     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-05-14     Completed Date:  1987-05-14     Revised Date:  2006-11-03    
Medline Journal Info:
Nlm Unique ID:  0155112     Medline TA:  Lymphology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  146-52     Citation Subset:  IM    
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MeSH Terms
Elephantiasis, Filarial / complications,  pathology*
Lymphatic System / pathology*
Lymphedema / pathology*
Microscopy, Electron, Scanning
Thrombosis / classification,  etiology,  pathology*

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