| Evolution and involution of atherosclerosis and its relationship with vascular reactivity in hypercholesterolemic rabbits. | |
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MedLine Citation:
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PMID: 22024507 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: The aim of this study is to verify the evolution and involution of experimental atherosclerosis in rabbits through the study of endothelial function, lipids and tissue lipid peroxidation, macro and microscopic quantification of aortic atherosclerosis. METHODS: Thirty male New Zealand white rabbits were divided into six groups (n=5): G1 normal diet; G2: hypercholesterolemic receiving 0.5% of cholesterol diet for 4months; G3: hypercholesterolemic diet for 4months after normal diet for more 4months; G4: hypercholesterolemic diet for 4months plus normal diet and rosuvastatin for 1month, G5: hypercholesterolemic diet for 4months plus normal diet and rosuvastatin for 2months, G6: hypercholesterolemic diet for 4months plus normal diet and rosuvastatin for 4months. Rosuvastatin was administered at a dosage of 5mg dissolved in 150ml of water daily. At the end of the experiment were measured: total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), tissue cholesterol (CAO), lipid peroxidation tissue (MDA). Endothelial function (RMAX) was studied in a segment of thoracic aorta, through curve-effect of acetylcholine and sodium nitroprusside. The amount of atherosclerosis was determined by measurement of the arterial lesion, through software, after staining with Sudan IV and histological staining. RESULTS: In relation the water the rabbits drank 60-70ml all day. It was seen significantly increase in all parameters at G2 both biochemical and tissue. In the group G3 it was seen significantly decrease in plasma lipids levels and tissue cholesterol. Treated groups G4, G5 and G6 all showed a decreased plasma lipid levels, only at G6 group it was noted a tissue cholesterol, tissue peroxidation and quantification of atherosclerosis, which showed a significant decrease. In relation the endothelial function only G6 improve significantly. INTERPRETATION AND CONCLUSIONS: Our findings indicated that the treatment with rosuvastatin for 4months is more efficient because improve the endothelial function significantly. |
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Authors:
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Michiko Regina Ozaki; Eros Antonio de Almeida |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-22 |
Journal Detail:
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Title: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie Volume: - ISSN: 1618-1433 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier GmbH. All rights reserved. |
Affiliation:
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Laboratory of Endothelium, Lipids and Atherosclerosis, Center of Experimental Medicine and Surgery, Faculty of Medical Science, University of Campinas (UNICAMP), State of São Paulo, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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