| Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. | |
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MedLine Citation:
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PMID: 21038418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whereas in most cases a fatty liver remains free of inflammation, 10%-20% of patients who have fatty liver develop inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]). Inflammation may precede steatosis in certain instances. Therefore, NASH could reflect a disease where inflammation is followed by steatosis. In contrast, NASH subsequent to simple steatosis may be the consequence of a failure of antilipotoxic protection. In both situations, many parallel hits derived from the gut and/or the adipose tissue may promote liver inflammation. Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH. |
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Authors:
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Herbert Tilg; Alexander R Moschen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 52 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 1836-46 Citation Subset: IM |
Affiliation:
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Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Innsbruck, Austria. herbert.tilg@i-med.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diet Disease Progression Fatty Liver / chemically induced, etiology, physiopathology* Humans Inflammation / complications, physiopathology* Interleukin-5 / adverse effects, genetics Leptin / adverse effects, physiology Metabolic Diseases / complications, etiology, physiopathology Models, Biological Obesity / complications Trans Fatty Acids / adverse effects Tumor Necrosis Factor-alpha / adverse effects, genetics |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-5; 0/Leptin; 0/Trans Fatty Acids; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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