Document Detail


Evolution in the assessment and management of trigeminal schwannoma.
MedLine Citation:
PMID:  18090871     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
EDUCATIONAL OBJECTIVE: At the conclusion of this presentation, the participants should be able to understand the contemporary assessment and management algorithm used in the evaluation and care of patients with trigeminal schwannomas. OBJECTIVES: 1) Describe the contemporary neuroradiographic studies for the assessment of trigeminal schwannoma; 2) review the complex skull base osteology involved with these lesions; and 3) describe a contemporary management algorithm. STUDY DESIGN: Retrospective review of 23 cases. METHODS: Chart review. RESULTS: From 1984 to 2006, of 23 patients with trigeminal schwannoma (10 males and 13 females, ages 14-77 years), 15 patients underwent combined transpetrosal extirpation, 5 patients underwent stereotactic radiation, and 3 were followed without intervention. Of the 15 who underwent surgery, total tumor removal was achieved in 9 patients. Cytoreductive surgery was performed in six patients; of these, four received postoperative radiation. One patient who underwent primary radiation therapy required subsequent surgery. There were no deaths in this series. Cranial neuropathies were present in 14 patients pretreatment and observed in 17 patients posttreatment. Major complications included meningitis (1), cerebrospinal fluid leakage (2), major venous occlusion (1), and temporal lobe infarction (1). CONCLUSIONS: Trigeminal schwannomas are uncommon lesions of the skull base that may occur in the middle fossa, posterior fossa, or both. Moreover, caudal extension results in their presentation in the infratemporal fossa. Contemporary diagnostic imaging, coupled with selective use of both surgery and radiation will limit morbidity and allow for the safe and prudent management of this uncommon lesion.
Authors:
Bharat Guthikonda; Philip V Theodosopoulos; Harry van Loveren; John M Tew; Myles L Pensak
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  118     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-27     Completed Date:  2008-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-203     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0515, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Combined Modality Therapy
Diagnosis, Differential
Humans
Magnetic Resonance Imaging
Middle Aged
Neurilemmoma* / pathology,  radiotherapy,  surgery
Otorhinolaryngologic Surgical Procedures / methods*
Radiosurgery / instrumentation
Retrospective Studies
Skull Base Neoplasms* / pathology,  radiotherapy,  surgery
Trigeminal Nerve* / pathology,  radiation effects,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dual action of TGF-beta1 on nasal-polyp derived fibroblasts.
Next Document:  B-type natriuretic peptide after hormone therapy in postmenopausal women with chest pain and normal ...