Document Detail


Evolution of human Polyomavirus JC: implications for the population history of humans.
MedLine Citation:
PMID:  11847555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The polyomavirus JC virus (JCV), the etiological agent of progressive multifocal leukoencephalopathy, is ubiquitous in the human population, infecting children asymptomatically, then persisting in the kidney. The main mode of transmission of JCV is from parents to children through long-term cohabitation. Twelve JCV subtypes that occupy unique domains in Europe, Africa, and Asia have been identified. Here, we attempted to elucidate the evolutionary relationships among JCV strains worldwide using the whole-genome approach with which a highly reliable phylogeny of JCV strains can be reconstructed. Sixty-five complete JCV DNA sequences, derived from various geographical regions and belonging to 11 of the 12 known subtypes, were subjected to phylogenetic analysis using three independent methods: the neighbor-joining, maximum parsimony, and maximum likelihood methods. The trees obtained with these methods consistently indicated that ancestral JCVs were divided into three superclusters, designated as Types A, B, and C. A split in Type A generated two subtypes, EU-a and -b, mainly containing European and Mediterranean strains. The first split in Type B generated Af2 (the major African subtype). Subsequent splits in Type B generated B1-c (a minor European subtype) and all seven Asian subtypes (B1-a, -b, -d, B2, MY, CY, and SC). Type C generated a single subtype (Af1), consisting of strains derived from western Africa. While the present findings provided a basis on which to classify JCV into types or subtypes, they have several implications for the divergence and migration of human populations.
Authors:
Chie Sugimoto; Masami Hasegawa; Atsushi Kato; Huai-Ying Zheng; Hideki Ebihara; Fumiaki Taguchi; Tadaichi Kitamura; Yoshiaki Yogo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular evolution     Volume:  54     ISSN:  0022-2844     ISO Abbreviation:  J. Mol. Evol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-15     Completed Date:  2002-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0360051     Medline TA:  J Mol Evol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  285-97     Citation Subset:  IM    
Affiliation:
Laboratory of Viral Infection, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Evolution, Molecular*
Genetics, Population*
Humans
JC Virus / genetics*
Molecular Sequence Data
Phylogeny*
Sequence Alignment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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