Document Detail


Evolution of hippocampal spatial representation over time in mice.
MedLine Citation:
PMID:  23084879     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To investigate the intriguing and paradoxical contrast between the time-limited role of the hippocampus in memory consolidation and its permanent contribution to spatial memory as revealed by place cell activity, we carefully monitored the temporal evolution of the same set of place cells in normal naïve mice throughout their familiarization to a spatial context and their consolidation of memory about space. Over six daily recording sessions, despite their widely reported stability, we observed gradual changes in hippocampal place fields and cell firing patterns. These changes were interpreted in terms of both improvement and impoverishment of spatial codes: improvement due to intrinsic place cell plasticity, and impoverishment as a consequence of attentional filtering of allocentric spatial information reaching the hippocampus due to the procedural behavioral requirements of the task, or to hippocampal disengagement as learning progresses.
Authors:
Yannick Jeantet; Yoon H Cho
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-16
Journal Detail:
Title:  Neurobiology of learning and memory     Volume:  -     ISSN:  1095-9564     ISO Abbreviation:  Neurobiol Learn Mem     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508166     Medline TA:  Neurobiol Learn Mem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, CNRS UMR 5287, Avenue des Facultés, 33405 Talence Cedex, France.
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