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Evolution of haptoglobin: comparison of complementary DNA encoding Hp alpha 1S and Hp alpha 2FS.
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MedLine Citation:
PMID:  6330675     Owner:  NLM     Status:  MEDLINE    
Haptoglobin is a transport glycoprotein which removes free hemoglobin from the circulation of vertebrates. In human populations haptoglobin is polymorphic due to three alleles, Hp alpha 1F, Hp alpha 1S and Hp alpha 2. The Hp alpha 2 allele is roughly twice the length of the Hp alpha 1 alleles and is the product of a partial gene duplication possibly resulting from an unequal crossover event in a heterozygous genotype Hp alpha 1F/Hp alpha 1S. In the study described here we compare the cDNA encoding Hp alpha 1S to that encoding Hp alpha 2FS . Both have a leader sequence followed by the genotypic alpha chain sequence, a beta sequence and an untranslated sequence in the 3' end. The cDNA encoding Hp alpha 2FS is composed of alpha 1F and alpha 1S domains differing by four nucleotide replacements. Hp alpha 1S cDNA contains the same replacement site mutations found in the alpha 1S domain of Hp alpha 2FS , indicating that this coding region has sustained few, if any, mutations since its incorporation into the Hp alpha 2FS gene.
J L Brune; F Yang; D R Barnett; B H Bowman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nucleic acids research     Volume:  12     ISSN:  0305-1048     ISO Abbreviation:  Nucleic Acids Res.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-27     Completed Date:  1984-07-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0411011     Medline TA:  Nucleic Acids Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  4531-8     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Base Sequence
Cloning, Molecular*
DNA / analysis*
DNA Restriction Enzymes
Haptoglobins / genetics*
Liver / metabolism
Macromolecular Substances
Polymorphism, Genetic*
Grant Support
Reg. No./Substance:
0/Haptoglobins; 0/Macromolecular Substances; 9007-49-2/DNA; EC 3.1.21.-/DNA Restriction Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Nucleic Acids Res
ISSN: 0305-1048
ISSN: 1362-4962
Article Information
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Print publication date: Day: 11 Month: 6 Year: 1984
Volume: 12 Issue: 11
First Page: 4531 Last Page: 4538
ID: 318856
PubMed Id: 6330675

Evolution of haptoglobin: comparison of complementary DNA encoding Hp alpha 1S and Hp alpha 2FS.
J L Brune
F Yang
D R Barnett
B H Bowman

Article Categories:
  • Research Article

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