Document Detail


Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice.
MedLine Citation:
PMID:  21374661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Our study suggests that the majority of the current knowledge about genomic changes in HCC is based on advanced tumor lesions and that systematic analyses of the chronologic order including early lesions may reveal new, unexpected findings.
Authors:
Kristina Aleksic; Carolin Lackner; Jochen B Geigl; Martina Schwarz; Martina Auer; Peter Ulz; Maria Fischer; Zlatko Trajanoski; Marcus Otte; Michael R Speicher
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  53     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-04     Completed Date:  2011-05-12     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  895-904     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Association for the Study of Liver Diseases.
Affiliation:
Institute of Human Genetics, Medical University of Graz, Graz, Austria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Hepatocellular / chemically induced,  genetics
Comparative Genomic Hybridization
Core Binding Factor Alpha 3 Subunit / genetics
DNA Copy Number Variations
Diethylnitrosamine
Genomic Instability*
Humans
Liver Neoplasms / chemically induced,  genetics
Male
Mice
Receptors, Cytoplasmic and Nuclear / genetics
beta Catenin / genetics
Chemical
Reg. No./Substance:
0/Core Binding Factor Alpha 3 Subunit; 0/Receptors, Cytoplasmic and Nuclear; 0/Runx3 protein, mouse; 0/beta Catenin; 0/nuclear receptor subfamily 0, group B, member 2; 55-18-5/Diethylnitrosamine
Comments/Corrections
Comment In:
Hepatology. 2011 Mar;53(3):723-5   [PMID:  21374655 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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