| Evolution from empirical dynamic contrast-enhanced magnetic resonance imaging to pharmacokinetic MRI. | |
| | |
MedLine Citation:
|
PMID: 10699307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
For chemotherapy to be effective against cancers which grow as solid tumors, agents must reach all tumor cells in effective quantities. Although many clinical trials include studies of the pharmacokinetics of the agents in body fluids such as blood or cerebrospinal fluid (CSF), there is presently no widely applicable way to determine access of chemotherapeutic agents to all regions of a solid tumor in an individual patient. This review discusses a relatively new methodology in MR imaging - dynamic contrast-enhanced imaging for exploring tumor microcirculation and drug access by imaging the uptake, or leakage, of contrast agent into tumor interstitial (extracellular and extravascular) space. The aims and methods of dynamic contrast-enhanced MRI evaluations to measure contrast uptake are distinguished from dynamic contrast-enhanced MRI to measure blood volume or flow, by MR imaging of the first-pass effects of a contrast bolus. Measures of contrast uptake by dynamic MRI have demonstrated a convincing ability to aid in diagnosing the presence of viable tumor and to measure response for a range of human tumors. This body of clinical results will be summarized. While questions remain to be answered about how to extract non-invasive pharmacokinetic measures of drug access from these novel dynamic imaging methods, we are optimistic that these methods can provide important new clinical measures that reflect the range of biological variation within and between naturally-occurring solid tumors. |
| | |
Authors:
|
J S Taylor; W E Reddick |
Related Documents
:
|
20512547 - Gadolinium-enhanced dynamic magnetic resonance imaging with endorectal coil for local s... 3659367 - Upper airway obstruction in infants and children: evaluation with ultrafast ct. 3966127 - Dynamic computed tomography of the head and neck: differential diagnostic value. 9216777 - Dynamic mri using a surface coil in chronic cholecystitis and gallbladder carcinoma: ra... 8180857 - Ultrasonography in medical imaging. influence on diagnostic routines. 3336677 - Chordomas: mr imaging. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Advanced drug delivery reviews Volume: 41 ISSN: 0169-409X ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2000 Mar |
Date Detail:
|
Created Date: 2000-07-19 Completed Date: 2000-07-19 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 91-110 Citation Subset: IM |
Affiliation:
|
Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794, USA. june.taylor@stjude.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood-Brain Barrier Humans Image Enhancement* Magnetic Resonance Imaging* Models, Biological Neoplasms / diagnosis Neovascularization, Pathologic / diagnosis Pharmacokinetics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Monitoring pharmacokinetics of anticancer drugs: non-invasive investigation using magnetic resonance...
Next Document: Noninvasive measurements for studying the tumoral pharmacokinetics of platinum anticancer drugs in s...