Document Detail

Evolution of the first metabolic cycles.
MedLine Citation:
PMID:  2296579     Owner:  NLM     Status:  MEDLINE    
There are two alternatives concerning the origin of life: the origin may be heterotrophic or autotrophic. The central problem within the theory of an autotrophic origin is the first process of carbon fixation. I here propose the hypothesis that this process is an autocatalytic cycle that can be retrodictively constructed from the extant reductive citric acid cycle by replacing thioesters by thioacids and by assuming that the required reducing power is obtained from the oxidative formation of pyrite (FeS2). This archaic cycle is strictly chemoautotrophic: photoautotrophy is not required. The cycle is catalytic for pyrite formation and autocatalytic for its own multiplication. It is a consequence of this hypothesis that the postulated cycle cannot exist as a single isolated cycle but must be a member of a network of concatenated homologous cycles, from which all anabolic pathways appear to have sprung.
G Wächtershäuser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  87     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-09     Completed Date:  1990-02-09     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  200-4     Citation Subset:  IM; S    
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MeSH Terms
Citric Acid Cycle
Models, Theoretical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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