Document Detail

Evolution of electrosensory ampullary organs: conservation of Eya4 expression during lateral line development in jawed vertebrates.
MedLine Citation:
PMID:  23017075     Owner:  NLM     Status:  MEDLINE    
The lateral line system of fishes and amphibians comprises two ancient sensory systems: mechanoreception and electroreception. Electroreception is found in all major vertebrate groups (i.e. jawless fishes, cartilaginous fishes, and bony fishes); however, it was lost in several groups including anuran amphibians (frogs) and amniotes (reptiles, birds, and mammals), as well as in the lineage leading to the neopterygian clade of bony fishes (bowfins, gars, and teleosts). Electroreception is mediated by modified "hair cells," which are collected in ampullary organs that flank lines of mechanosensory hair cell containing neuromasts. In the axolotl (a urodele amphibian), grafting and ablation studies have shown a lateral line placode origin for both mechanosensory neuromasts and electrosensory ampullary organs (and the neurons that innervate them). However, little is known at the molecular level about the development of the amphibian lateral line system in general and electrosensory ampullary organs in particular. Previously, we identified Eya4 as a marker for lateral line (and otic) placodes, neuromasts, and ampullary organs in a shark (a cartilaginous fish) and a paddlefish (a basal ray-finned fish). Here, we show that Eya4 is similarly expressed during otic and lateral line placode development in the axolotl (a representative of the lobe-finned fish clade). Furthermore, Eya4 expression is specifically restricted to hair cells in both neuromasts and ampullary organs, as identified by coexpression with the calcium-buffering protein Parvalbumin3. As well as identifying new molecular markers for amphibian mechanosensory and electrosensory hair cells, these data demonstrate that Eya4 is a conserved marker for lateral line placodes and their derivatives in all jawed vertebrates.
Melinda S Modrell; Clare V H Baker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Evolution & development     Volume:  14     ISSN:  1525-142X     ISO Abbreviation:  Evol. Dev.     Publication Date:    2012 May-Jun
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-02-22     Revised Date:  2014-11-12    
Medline Journal Info:
Nlm Unique ID:  100883432     Medline TA:  Evol Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-85     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
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MeSH Terms
Ambystoma mexicanum / embryology*,  genetics,  metabolism
Biological Evolution*
Eye Proteins / genetics,  metabolism*
Gene Expression Regulation, Developmental*
Hair Cells, Ampulla / metabolism*
Lateral Line System / embryology*,  metabolism
Mechanoreceptors / metabolism
Parvalbumins / metabolism
Trans-Activators / genetics,  metabolism*
Grant Support
BB/F00818X/1//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Eye Proteins; 0/Parvalbumins; 0/Trans-Activators

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