Document Detail

Evolution of dosage compensation.
MedLine Citation:
PMID:  8793201     Owner:  NLM     Status:  MEDLINE    
In polytene chromosome squashes from the fruit fly Drosophila melanogaster, the single, dosage-compensated X chromosome in males can be distinguished from the autosomes by the presence of an isoform of histone H4 acetylated at lysine 16, H4.Ac16. We have used H4.Ac16 as a marker to examine the evolving relationship between dosage compensation and sex chromosome composition in species of Drosophila with one (D. melanogaster), two (D. pseudoobscura) or three (D. miranda) identifiable X chromosome arms. In each case, we find that H4.Ac16 is distributed as discrete, closely spaced bands along the entire length of each X chromosome, the only exception being the X2 chromosome of D. miranda in which a terminal region constituting about 10% of the chromosome by length is not labelled with anti-H4.Ac16 antibodies. We conclude that, with this exception, dosage compensation extends along the X chromosomes of all three species. As D. pseudoobscura and D. miranda diverged only about 2 Mya, the spread of dosage-compensated loci along X2 has been rapid, suggesting that regional changes rather than piecemeal, gene-by-gene, changes may have been involved.
M Steinemann; S Steinemann; B M Turner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology     Volume:  4     ISSN:  0967-3849     ISO Abbreviation:  Chromosome Res.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-12-09     Completed Date:  1996-12-09     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  9313452     Medline TA:  Chromosome Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Institut für Genetik, Heinrich Heine Universität Düsseldorf, Germany.
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MeSH Terms
Dosage Compensation, Genetic*
Drosophila / classification,  genetics*,  growth & development
Drosophila melanogaster / genetics,  growth & development
Evolution, Molecular*
Fluorescent Antibody Technique, Indirect
Histones / analysis,  metabolism
Protein Processing, Post-Translational
Species Specificity
X Chromosome / chemistry,  genetics*
Grant Support
//Wellcome Trust
Reg. No./Substance:

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