Document Detail

Evolution of collagens.
MedLine Citation:
PMID:  12382326     Owner:  NLM     Status:  MEDLINE    
The extracellular matrix is often defined as the substance that gives multicellular organisms (from plants to vertebrates) their structural integrity, and is intimately involved in their development. Although the general functions of extracellular matrices are comparable, their compositions are quite distinct. One of the specific components of metazoan extracellular matrices is collagen, which is present in organisms ranging from sponges to humans. By comparing data obtained in diploblastic, protostomic, and deuterostomic animals, we have attempted to trace the evolution of collagens and collagen-like proteins. Moreover, the collagen story is closely involved with the emergence and evolution of metazoa. The collagen triple helix is one of numerous modules that arose during the metazoan radiation which permit the formation of large multimodular proteins. One of the advantages of this module is its involvement in oligomerization, in which it acts as a structural organizer that is not only relatively resistant to proteases but also permits the creation of multivalent supramolecular networks.
Jean-Yves Exposito; Caroline Cluzel; Robert Garrone; Claire Lethias
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Anatomical record     Volume:  268     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-16     Completed Date:  2003-04-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  United States    
Other Details:
Languages:  eng     Pagination:  302-16     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Institut de Biologie et Chimie des Protéines, Université Claude Bernard, Lyon, France.
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MeSH Terms
Collagen* / chemistry,  classification,  physiology
Evolution, Molecular
Extracellular Matrix / chemistry,  physiology*
Extracellular Matrix Proteins / chemistry
Models, Biological
Reg. No./Substance:
0/Extracellular Matrix Proteins; 9007-34-5/Collagen

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