| Evolution of the cancer genome. | |
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MedLine Citation:
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PMID: 23044827 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The advent of massively parallel sequencing technologies has allowed the characterization of cancer genomes at an unprecedented resolution. Investigation of the mutational landscape of tumours is providing new insights into cancer genome evolution, laying bare the interplay of somatic mutation, adaptation of clones to their environment and natural selection. These studies have demonstrated the extent of the heterogeneity of cancer genomes, have allowed inferences to be made about the forces that act on nascent cancer clones as they evolve and have shown insight into the mutational processes that generate genetic variation. Here we review our emerging understanding of the dynamic evolution of the cancer genome and of the implications for basic cancer biology and the development of antitumour therapy. |
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Authors:
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Lucy R Yates; Peter J Campbell |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-09 |
Journal Detail:
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Title: Nature reviews. Genetics Volume: - ISSN: 1471-0064 ISO Abbreviation: Nat. Rev. Genet. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962779 Medline TA: Nat Rev Genet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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