Document Detail

Evolution of the cancer genome.
MedLine Citation:
PMID:  23044827     Owner:  NLM     Status:  MEDLINE    
The advent of massively parallel sequencing technologies has allowed the characterization of cancer genomes at an unprecedented resolution. Investigation of the mutational landscape of tumours is providing new insights into cancer genome evolution, laying bare the interplay of somatic mutation, adaptation of clones to their environment and natural selection. These studies have demonstrated the extent of the heterogeneity of cancer genomes, have allowed inferences to be made about the forces that act on nascent cancer clones as they evolve and have shown insight into the mutational processes that generate genetic variation. Here we review our emerging understanding of the dynamic evolution of the cancer genome and of the implications for basic cancer biology and the development of antitumour therapy.
Lucy R Yates; Peter J Campbell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-09
Journal Detail:
Title:  Nature reviews. Genetics     Volume:  13     ISSN:  1471-0064     ISO Abbreviation:  Nat. Rev. Genet.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-18     Completed Date:  2013-01-04     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  100962779     Medline TA:  Nat Rev Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  795-806     Citation Subset:  IM    
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MeSH Terms
Evolution, Molecular
Gene-Environment Interaction
Genetic Predisposition to Disease / genetics*
Genome, Human / genetics
Models, Genetic
Neoplasms / genetics*
Selection, Genetic
Grant Support
088340//Wellcome Trust; 093867//Wellcome Trust; //Wellcome Trust

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