| Evolution of brain tuberculomas under standard antituberculous treatment. | |
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MedLine Citation:
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PMID: 9559986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The treatment of brain tuberculomas is primarily medical. Surgery, excision or biopsy, is generally performed when the diagnosis is in doubt or there is no response to medical therapy. The aim of this study was to determine the radiological evolution of intracranial tuberculomas under standard anti-tuberculous drug therapy and to establish guidelines for better management of these patients. Eighteen patients were studied retrospectively. None of them had surgical intervention and all were treated by standard antituberculous drugs and had serial computed tomography (CT) scans until disappearance or stabilization of brain lesions. The regression of lesions' size and number was slow in the first month (mean -7.3%) then became rapid after this (-15% to -20% per month). A paradoxical increase in size was noted in three patients in the first month. All three had associated meningitis. All tuberculomas disappeared on CT scan after 12 months of therapy. Most of the edema images disappeared by 6 months. This study would suggest that a long treatment regimen of 15-18 months may not be necessary in most intracranial tuberculomas occurring in non-immunocompromised patients. It also demonstrates that medical trial in well tolerated suspected cases should last for at least 2 months before considering other etiologies or surgical exploration. |
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Authors:
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A Awada; A K Daif; M Pirani; M Y Khan; Z Memish; S Al Rajeh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 156 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1998 |
Date Detail:
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Created Date: 1998-06-16 Completed Date: 1998-06-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 47-52 Citation Subset: IM |
Affiliation:
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Neurology Section, King Fahad National Guard Hospital, Riyadh, Saudi Arabia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Antitubercular Agents / adverse effects* Brain Diseases / etiology*, radiography Female Humans Male Middle Aged Tuberculoma / etiology*, radiography Tuberculosis / complications, drug therapy, radiography |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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