| Evolution, body composition, insulin receptor competition, and insulin resistance. | |
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MedLine Citation:
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PMID: 19686772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Better understanding of the relationships between body composition and insulin resistance. RESULTS: Average human adiposity and sarcopenia have attained unprecedented levels and the resultantly abnormal body composition distorts insulin receptor balance. Compared to evolutionary norms we now have too many adipocyte insulin receptors (in adipose tissue and liver) and too few myocyte insulin receptors. The body's insulin receptors can be conceptualized as competing for insulin molecules released from the pancreas. When an insulin molecule docks on an adipocyte receptor, substantially fewer glucose molecules are cleared from the blood than when an insulin molecule docks on a myocyte insulin receptor. Populational insulin receptor imbalance would seem to parallel the secular rise in insulin resistance and offers an attractive pathophysiological explanation for the accompanying type 2 diabetes epidemic. CONCLUSION: An evolutionary perspective regarding body composition, insulin receptor imbalance, and the consequent impact on carbohydrate metabolism should enhance public acceptance of recommendations to increase physical activity. |
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Authors:
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S Boyd Eaton; Loren Cordain; Phillip B Sparling |
Publication Detail:
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Type: Journal Article; Review Date: 2009-08-15 |
Journal Detail:
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Title: Preventive medicine Volume: 49 ISSN: 1096-0260 ISO Abbreviation: Prev Med Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-23 Completed Date: 2011-01-04 Revised Date: 2011-01-18 |
Medline Journal Info:
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Nlm Unique ID: 0322116 Medline TA: Prev Med Country: United States |
Other Details:
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Languages: eng Pagination: 283-5 Citation Subset: IM |
Affiliation:
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Department of Anthropology, Emory University, 2887 Howell Mill NW, Atlanta, GA 30327, USA. sboydeaton@comcast.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism Adiposity Biological Evolution* Body Composition* Diabetes Mellitus, Type 2 / etiology Humans Insulin / secretion Insulin Resistance* Insulin-Secreting Cells / secretion Life Style* Muscle Cells / metabolism Receptor, Insulin / metabolism* Risk Factors |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; EC 2.7.10.1/Receptor, Insulin |
| Comments/Corrections | |
Erratum In:
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Prev Med. 2011 Jan;52(1):95 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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