Document Detail


Evolution of an avian H5N1 influenza A virus escape mutant.
MedLine Citation:
PMID:  24255886     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the genetic constitution of an escape mutant H5N1 strain and to screen the presence of possible amino acid signatures that could differentiate it from other Egyptian H5N1 strains.
METHODS: Phylogenetic, evolutionary patterns and amino acid signatures of the genes of an escape mutant H5N1 influenza A virus isolated in Egypt on 2009 were analyzed using direct sequencing and multisequence alignments.
RESULTS: All the genes of the escape mutant H5N1 strain showed a genetic pattern potentially related to Eurasian lineages. Evolution of phylogenetic trees of different viral genes revealed the absence of reassortment in the escape mutant strain while confirming close relatedness to other H5N1 Egyptian strains from human and avian species. A variety of amino acid substitutions were recorded in different proteins compared to the available Egyptian H5N1 strains. The strain displayed amino acid substitutions in different viral alleles similar to other Egyptian H5N1 strains without showing amino acid signatures that could differentiate the escape mutant from other Egyptian H5N1.
CONCLUSION: The genetic characteristics of avian H5N1 in Egypt revealed evidence of a high possibility of inter-species transmission. No amino acid signatures were found to differentiate the escape mutant H5N1 strain from other Egyptian H5N1 strains.
Authors:
Kamel M A Hassanin; Ahmed S Abdel-Moneim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of virology     Volume:  2     ISSN:  2220-3249     ISO Abbreviation:  World J Virol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-22     Completed Date:  2013-11-22     Revised Date:  2013-12-16    
Medline Journal Info:
Nlm Unique ID:  101608353     Medline TA:  World J Virol     Country:  China    
Other Details:
Languages:  eng     Pagination:  160-9     Citation Subset:  -    
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