| The evolution of vascular tissue engineering and current state of the art. | |
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MedLine Citation:
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PMID: 21996786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dacron® (polyethylene terephthalate) and Goretex® (expanded polytetrafluoroethylene) vascular grafts have been very successful in replacing obstructed blood vessels of large and medium diameters. However, as diameters decrease below 6 mm, these grafts are clearly outperformed by transposed autologous veins and, particularly, arteries. With approximately 8 million individuals with peripheral arterial disease, over 500,000 patients diagnosed with end-stage renal disease, and over 250,000 patients per year undergoing coronary bypass in the USA alone, there is a critical clinical need for a functional small-diameter conduit [Lloyd-Jones et al., Circulation 2010;121:e46-e215]. Over the last decade, we have witnessed a dramatic paradigm shift in cardiovascular tissue engineering that has driven the field away from biomaterial-focused approaches and towards more biology-driven strategies. In this article, we review the preclinical and clinical efforts in the quest for a tissue-engineered blood vessel that is free of permanent synthetic scaffolds but has the mechanical strength to become a successful arterial graft. Special emphasis is given to the tissue engineering by self-assembly (TESA) approach, which has been the only one to reach clinical trials for applications under arterial pressure. |
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Authors:
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Marissa Peck; David Gebhart; Nathalie Dusserre; Todd N McAllister; Nicolas L'Heureux |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-10-13 |
Journal Detail:
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Title: Cells, tissues, organs Volume: 195 ISSN: 1422-6421 ISO Abbreviation: Cells Tissues Organs (Print) Publication Date: 2012 |
Date Detail:
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Created Date: 2011-12-19 Completed Date: 2012-04-09 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 100883360 Medline TA: Cells Tissues Organs Country: Switzerland |
Other Details:
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Languages: eng Pagination: 144-58 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Cytograft Tissue Engineering Inc., Novato, Calif., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessel Prosthesis* Humans Materials Testing Tissue Engineering / methods* Tissue Scaffolds / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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R43HL105010/HL/NHLBI NIH HHS; R44HL064462/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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