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Evolution of the Urinary Proteome during Human Renal Development and Maturation: Variations with Gestational and Postnatal Age.
MedLine Citation:
PMID:  22580717     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:Low birth weight is associated with deficits in nephron number in the infant kidney and increased risk of adulthood hypertension and renal dysfunction. Urinary biomarkers may be potential indicators of renal reserve, but little is known about the influence of gestational and postnatal age on the expression of urinary proteins. The aims of this study were to determine the relationships between selected urinary proteins and renal maturation. We hypothesized that urinary protein patterns would change over time during late nephrogenesis and renal maturation.Methods:Urine samples were collected at birth and over 12 months from preterm (33-35 weeks) and term (38-40 weeks) infants. Candidate urinary proteins were identified by antibody array and quantified with ELISA.Results:Preterm infants at birth were found to have relatively elevated levels of IGFBP-1, -2, -6 (Insulin-like Growth Factor Binding Protein-1, -2, -6), MCP-1(Monocyte Chemotactic Protein-1), CD14 and Siglec-5 (Sialic acid-binding Ig-like lectin 5). These markers gradually decline to levels similar to full term infants by two to six months old. In contrast, many urinary markers in healthy full term infants remain stable over the first year of life.Conclusions:Gestational and postnatal age must be considered when evaluating the utility of urinary biomarkers.
Authors:
Jennifer R Charlton; Victoria F Norwood; Susan S Kiley; Matthew J Gurka; Robert L Chevalier
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-11
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908.
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