| Evolution of the Urinary Proteome during Human Renal Development and Maturation: Variations with Gestational and Postnatal Age. | |
| | |
MedLine Citation:
|
PMID: 22580717 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background:Low birth weight is associated with deficits in nephron number in the infant kidney and increased risk of adulthood hypertension and renal dysfunction. Urinary biomarkers may be potential indicators of renal reserve, but little is known about the influence of gestational and postnatal age on the expression of urinary proteins. The aims of this study were to determine the relationships between selected urinary proteins and renal maturation. We hypothesized that urinary protein patterns would change over time during late nephrogenesis and renal maturation.Methods:Urine samples were collected at birth and over 12 months from preterm (33-35 weeks) and term (38-40 weeks) infants. Candidate urinary proteins were identified by antibody array and quantified with ELISA.Results:Preterm infants at birth were found to have relatively elevated levels of IGFBP-1, -2, -6 (Insulin-like Growth Factor Binding Protein-1, -2, -6), MCP-1(Monocyte Chemotactic Protein-1), CD14 and Siglec-5 (Sialic acid-binding Ig-like lectin 5). These markers gradually decline to levels similar to full term infants by two to six months old. In contrast, many urinary markers in healthy full term infants remain stable over the first year of life.Conclusions:Gestational and postnatal age must be considered when evaluating the utility of urinary biomarkers. |
| | |
Authors:
|
Jennifer R Charlton; Victoria F Norwood; Susan S Kiley; Matthew J Gurka; Robert L Chevalier |
Related Documents
:
|
10473327 - Mother-infant interaction in post-partum women with schizophrenia and affective disorders. 20980087 - Infant mortality, season of birth and the health of older puerto rican adults. 17539407 - Activity periods and questing behavior of the seabird tick ixodes uriae (acari: ixodida... 8829747 - Month of birth, hemisphere of birth and schizophrenia. 8374947 - No significant effect of an "atraumatic" needle on incidence of post-lumbar puncture he... 22371027 - Effect of grade i and ii intraventricular hemorrhage on visuocortical function in very ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-5-11 |
Journal Detail:
|
Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-5-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation.
Next Document: Neurally Adjusted Ventilatory Assist (NAVA) improves patient-ventilator interaction in infants compa...