Document Detail

Evolution of Pinnipedia lactation strategies: a potential role for alpha-lactalbumin?
MedLine Citation:
PMID:  17698445     Owner:  NLM     Status:  MEDLINE    
Despite the considerable variation in milk composition found among mammals, a constituent common across all groups is lactose, the main sugar and osmole in most eutherians milk. Exceptions to this are the families Otariidae (fur seals and sea lions) and Odobenidae (walruses), where lactose has not been detected. We investigated the molecular basis for this by cloning alpha-lactalbumin, the modifier protein of the lactose synthase complex. A mutation was observed which, in addition to preventing lactose production, may enable otariids to maintain lactation despite the extremely long inter-suckling intervals during the mother's time at sea foraging (more than 23 days in some species).
Coralie M Reich; John P Y Arnould
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology letters     Volume:  3     ISSN:  1744-9561     ISO Abbreviation:  Biol. Lett.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-15     Completed Date:  2007-10-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  101247722     Medline TA:  Biol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  546-9     Citation Subset:  IM    
CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria 3010, Australia.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Lactalbumin / genetics*
Molecular Sequence Data
Pinnipedia / genetics,  physiology*
Reg. No./Substance:

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