| Evolution of Pinnipedia lactation strategies: a potential role for alpha-lactalbumin? | |
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MedLine Citation:
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PMID: 17698445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the considerable variation in milk composition found among mammals, a constituent common across all groups is lactose, the main sugar and osmole in most eutherians milk. Exceptions to this are the families Otariidae (fur seals and sea lions) and Odobenidae (walruses), where lactose has not been detected. We investigated the molecular basis for this by cloning alpha-lactalbumin, the modifier protein of the lactose synthase complex. A mutation was observed which, in addition to preventing lactose production, may enable otariids to maintain lactation despite the extremely long inter-suckling intervals during the mother's time at sea foraging (more than 23 days in some species). |
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Authors:
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Coralie M Reich; John P Y Arnould |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biology letters Volume: 3 ISSN: 1744-9561 ISO Abbreviation: Biol. Lett. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-15 Completed Date: 2007-10-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 101247722 Medline TA: Biol Lett Country: England |
Other Details:
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Languages: eng Pagination: 546-9 Citation Subset: IM |
Affiliation:
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CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria 3010, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Evolution Lactalbumin / genetics* Lactation* Molecular Sequence Data Pinnipedia / genetics, physiology* |
| Chemical | |
Reg. No./Substance:
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9013-90-5/Lactalbumin |
| Comments/Corrections | |
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