| Evolution of IESs and scrambling in the actin I gene in hypotrichous ciliates. | |
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MedLine Citation:
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PMID: 11742064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Germ-line (micronuclear) genes in hypotrichous ciliates are interrupted by numerous, short, noncoding, AT-rich segments called internal eliminated segments, or IESs. IESs divide a gene into macronuclear destined segments, or MDSs. IESs are excised from micronuclear genes, and the MDSs are spliced when a micronuclear genome is processed into a macronuclear genome after cell mating. In the micronuclear version of the actin I gene intramolecular recombination between IESs during evolution has put MDSs into a scrambled disorder in some but not all hypotrichs. Studies using rDNA sequences to define phylogenetic relationships among eight hypotrichs suggests that evolution of the micronuclear actin I gene proceeds by successive addition of IESs in earlier diverging species, without MDS scrambling. Continued addition of IESs and recombination among IESs in later diverging species produced actin I genes with scrambled MDSs. Subsequent to MDS scrambling, additional IESs were inserted into the more recently evolved species. Thus, IES insertions and gene scrambling occur in a progressive manner during species evolution to produce micronuclear actin I genes of increasing structural complexity. |
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Authors:
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D J Hogan; E A Hewitt; K E Orr; D M Prescott; K M Müller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2001-12-11 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 98 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-25 Completed Date: 2002-01-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 15101-6 Citation Subset: IM |
Affiliation:
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Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309-034, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF188160; AY044837; AY044838; AY044839; AY046534; U63566 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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genetics* Animals Ciliophora / genetics* DNA, Ribosomal / genetics Evolution, Molecular* Humans Molecular Sequence Data Phylogeny |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM 56161/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/DNA, Ribosomal |
| Comments/Corrections | |
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