Document Detail

Evolution of Helicobacter pylori positivity in infants born from positive mothers.
MedLine Citation:
PMID:  7965484     Owner:  NLM     Status:  MEDLINE    
To evaluate the mother-child transmission of anti-Helicobacter pylori antibodies, we investigated 562 pregnant women by means of a commercially available second-generation enzyme-linked immunosorbent assay for the detection of anti-H. pylori IgG (Malakit Helicobacter pylori). One hundred twenty-eight of the 562 women had a positive serology for H. pylori. 13C-Urea breath tests were performed in 85 seropositive and in 65 randomly selected seronegative subjects. These breath tests were positive in 82 of the 85 (96.5%) seropositive and in none of the seronegative subjects, reflecting the actual presence of H. pylori in the gastric mucosa of the seropositive women. Cord blood levels for the Malakit Helicobacter pylori were positive in all infants born to seropositive mothers and negative in those born to seronegative mothers. In all infants the previously positive titers had turned negative by the age of 3 months. At the age of 12 to 15 months 13C-urea breath tests were performed in 67 infants born to seropositive mothers. These breath tests were positive in only one infant. By the time the 13C-urea breath tests were performed, the serology had turned negative in all infants with the exception of the one with the positive breath test. We conclude that the IgG antibodies against H. pylori cross the placental barrier and that, despite the present H. pylori infection in the mothers, infants born to these H. pylori-positive women do not appear to have an increased risk of developing a H. pylori-associated gastritis during the first year of life.
U Blecker; S Lanciers; E Keppens; Y Vandenplas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  19     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-09     Completed Date:  1994-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-90     Citation Subset:  IM    
Department of Pediatric Gastroenterology, Academic Children's Hospital, Brussels, Belgium.
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MeSH Terms
Antibodies, Bacterial / blood*
Breath Tests
Carbon Isotopes
Fetal Blood / immunology
Gastritis / microbiology
Helicobacter Infections / transmission*
Helicobacter pylori / immunology*
Infant, Newborn
Maternal-Fetal Exchange
Urea / diagnostic use
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Carbon Isotopes; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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