| Evolution of CpG islands within the myc gene family. | |
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MedLine Citation:
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PMID: 10991799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CpG islands are discrete regions of DNA with significantly greater frequencies of CpG doublets than bulk genomic DNA. They are most frequently associated with the 5'-ends of housekeeping genes and are involved in the regulation of their expression. In this study, the structure and evolution of CpG islands within genes of the myc family were evaluated with the protein-coding sequences of animals and their transducing viruses. These evaluations relied on a gene tree for the entire myc family to test the origins of CpG islands within their two protein-coding exons. Overall, CG-very rich and CG-rich islands are associated with exon 2 of the different myc genes of warm-blooded vertebrates and with exon 3 of the N-myc and s-myc sequences of mammals, but not birds. These overall distributions of well-developed islands can be related to the major transitions of the CG-rich genomes of warm-blooded vertebrates from the CG-poor ones of other animals. In turn, the greater variability of well-developed islands within exon 3 of the N-myc gene and among the different retrogenes of the myc family can be attributed to their reduced functional constraints, as evidenced by their limited and very restricted patterns of expression, respectively. |
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Authors:
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M M Miyamoto; N P Freire |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular phylogenetics and evolution Volume: 16 ISSN: 1055-7903 ISO Abbreviation: Mol. Phylogenet. Evol. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-10-20 Completed Date: 2000-10-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9304400 Medline TA: Mol Phylogenet Evol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 475-81 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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Department of Zoology, University of Florida, Gainesville, Florida 32611-8525, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Composition Codon CpG Islands / genetics* Databases, Factual Evolution, Molecular* Exons Genes, myc / genetics* Humans Phylogeny |
| Chemical | |
Reg. No./Substance:
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0/Codon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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