Document Detail


Evoked potentials in pediatric cerebral malaria.
MedLine Citation:
PMID:  22368773     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Cortical evoked potentials (EP) provide localized data regarding brain function and may offer prognostic information and insights into the pathologic mechanisms of malaria-mediated cerebral injury. As part of a prospective cohort study, we obtained somatosensory evoked potentials (SSEPs) and brainstem auditory EPs (AEPs) within 24 hours of admission on 27 consecutive children admitted with cerebral malaria (CM). Children underwent follow-up for 12 months to determine if they had any long term neurologic sequelae. EPs were obtained in 27 pediatric CM admissions. Two children died. Among survivors followed an average of 514 days, 7/25 (28.0%) had at least one adverse neurologic outcome. Only a single subject had absent cortical EPs on admission and this child had a good neurologic outcome. Among pediatric CM survivors, cortical EPs are generally intact and do not predict adverse neurologic outcomes. Further study is needed to determine if alterations in cortical EPs can be used to predict a fatal outcome in CM.
Authors:
Minal Bhanushali; Terrie E Taylor; Malcolm E Molyneux; Monica Sapuwa; Eunice Mwandira; Gretchen L Birbeck
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Publication Detail:
Type:  Journal Article     Date:  2011-12-06
Journal Detail:
Title:  Neurology international     Volume:  3     ISSN:  2035-8377     ISO Abbreviation:  Neurol Int     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-02-27     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101551564     Medline TA:  Neurol Int     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  e14     Citation Subset:  -    
Affiliation:
US National Institute of Health, 10-CRC Hatfield Research Center, Bethesda, USA;
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