Document Detail


Evoked otoacoustic emissions behaviour in retinitis pigmentosa.
MedLine Citation:
PMID:  7835186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hearing function was studied in 26 patients affected by retinitis pigmentosa (RP) and in their relatives. Sixteen patients showed bilateral normal hearing when examined with traditional audiometric methods. In these normoacusic patients evoked otoacoustic emissions (EOE) have been studied. The EOE offer a unique opportunity to measure objectively the function of outer hair cells: they record the amplitude of the energy produced by the outer hair cells of the coclea following an acoustic stimulation. The data have been statistically compared, using the Student's t-test, with those obtained in a homogeneous control-group of normal subjects. In normoacusic subjects with RP the average values of EOE intensity are statistically lower than those of normal subjects in 64 of the 127 frequency bands examined. Moreover, the distribution of the EOE in patients with retinitis pigmentosa proved to be more discontinous than that observed in the normal subjects. The EOE recorded in 14 normoacusic relatives show in some cases small anomalies but the data, on account of the limited sample group, cannot be statistically evaluated. Therefore a subclinical alteration of the Organ of Corti is found in 100% of the patients affected by RP, although they appear to be normoacusic to usual audiometric tests.
Authors:
C Fiore; C Cagini; P Menduno; I Toniassoni; A Desantis; A Pennacchi; G Ricci; E Molini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  87     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  167-76     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University of Perugia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Adolescent
Adult
Aged
Child
Cochlea
Female
Hair Cells, Auditory, Outer / physiology
Hearing Disorders / physiopathology
Hearing Tests / methods
Humans
Male
Middle Aged
Otoacoustic Emissions, Spontaneous / physiology*
Retinitis Pigmentosa / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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