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EVIDENCES THAT POLYMORPHISMS IN DETOXIFICATION GENES MODULATE THE SUSCEPTIBILITY FOR SPORADIC MEDULLARY THYROID CARCINOMA.
MedLine Citation:
PMID:  22048975     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Polymorphic low penetrance genes have been consistently associated with the susceptibility to a series of human tumors, including differentiated thyroid cancer. In order to determine their role in medullary thyroid cancer (MTC), we used TaqMan® SNP method to genotype 47 sporadic MTC and a control group of 578 healthy individuals for CYP1A2*F, CYP1A1m1, GSTP1, NAT2, and 72TP53. A logistic regression analysis showed that NAT2C/C (OR=3.87; 95%CI=2.11-7.10; p=2.2x10-5) and TP53C/C genotypes (OR=3.87; 95%CI=1.78-6.10; p=2.8x10-4) inheritance increased the risk of sporadic MTC. A stepwise regression analysis indicated that TP53C/C genotype contributes with 8.07% of the sporadic MTC risk. We were unable to identify any relationship between NAT2 and TP53 polymorphisms suggesting they are independent factors of risk to sporadic MTC. In addition, there was no association between the investigated genes and clinical or pathological features of aggressiveness of the tumors or the outcome of MTC patients. In conclusion, we demonstrated that detoxification genes and apoptotic and cell-cycle control genes are involved in the susceptibility of sporadic MTC and may modulate the susceptibility to the disease.
Authors:
Raquel Bueno Barbieri; Natassia Elena Bufalo; Rodrigo Secolin; Aline Carolina De Nadia da Silva; Ligia Vera M Assumpção; Rui M B Maciel; Janete Maria Cerutti; Laura Sterian Ward
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-2
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
R Barbieri, Medical Clinic, Unicamp, Campinas, CEP: 13083-887 , Brazil.
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