| Evidences for complex formation between L-dabPNA and aegPNA. | |
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MedLine Citation:
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PMID: 18707882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Continuing our research on the development of nucleopeptides as ODN analogs for biomedical and bioengineering applications, here we report the synthesis and the chemical-physical characterization of a homoadenine hexamer based on a l-diaminobutyric acid (l-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the l-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplex. |
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Authors:
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Giovanni N Roviello; Domenica Musumeci; Enrico M Bucci; Mariangela Castiglione; Annalisa Cesarani; Carlo Pedone; Gennaro Piccialli |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-06 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 18 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-29 Completed Date: 2008-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 4757-60 Citation Subset: IM |
Affiliation:
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Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, I-80134 Napoli, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine Nucleotides
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chemical synthesis,
chemistry,
metabolism Aminobutyric Acids / chemistry*, metabolism* Circular Dichroism DNA / chemistry, metabolism Drug Design Glycine / analogs & derivatives*, chemistry, metabolism Magnetic Resonance Spectroscopy Peptide Nucleic Acids / chemical synthesis, chemistry*, isolation & purification, metabolism* Spectrometry, Mass, Electrospray Ionization |
| Chemical | |
Reg. No./Substance:
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0/Adenine Nucleotides; 0/Aminobutyric Acids; 0/Peptide Nucleic Acids; 0/aminoethylglycyl PNA; 0/triplex DNA; 56-40-6/Glycine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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