Document Detail

Evidence for visceral hypersensitivity in high-anxiety rats.
MedLine Citation:
PMID:  10869605     Owner:  NLM     Status:  MEDLINE    
In patients with irritable bowel syndrome, anxiety is often associated with visceral pain. Based on this information we hypothesized that rats genetically predisposed to anxiety have an increased visceral sensitivity. To test this hypothesis, visceromotor reflex recordings in response to colorectal distention were used to estimate the level of visceral stimulation in high; moderate-, and low-anxiety rats. We compared the effect of innocuous colorectal distension in rats with and without sensitized colons. In nonsensitized rats visceromotor responses were increased by colorectal distention with the greatest response in the high-anxiety Wistar-Kyoto strain. Sensitization of the colon significantly increased visceromotor responses to colorectal distention in all rat strains. In summary, our data suggested that a manifestation of a genetically determined anxiety level appeared to be abnormal neural responsiveness of the gastrointestinal tract leading to visceral hypersensitivity in high-anxiety animals.
W D Gunter; J D Shepard; R D Foreman; D A Myers; B Greenwood-Van Meerveld
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  69     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-08-24     Completed Date:  2000-08-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  379-82     Citation Subset:  IM    
Oklahoma Foundation for Digestive Research, Basic Science Laboratories, V.A. Medical Center, Oklahoma City, OK 73104, USA.
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MeSH Terms
Acoustic Stimulation
Anxiety / genetics,  physiopathology*
Colon / physiology*
Corticosterone / blood
Electric Stimulation
Muscle Contraction / physiology
Rats, Inbred F344
Rats, Inbred WKY
Rats, Sprague-Dawley
Rectum / physiology*
Startle Reaction / physiology
Grant Support
Reg. No./Substance:

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