Document Detail

Evidence of vascular dysfunction in young patients with successfully repaired coarctation of aorta.
MedLine Citation:
PMID:  16115479     Owner:  NLM     Status:  MEDLINE    
It is well documented that in patients with coarctation of the aorta life expectancy is not normal even after successful coarctation repair (SCR), primarily due to cardiovascular events. We examined endothelial function in the forearm circulation, the mechanical properties and intima/media thickness in carotid and femoral arteries and the inflammatory process in normotensive patients, after coarctation repair. Fifteen patients, 29+/-2 years old, 12+/-2.9 years after SCR and 16 age- and sex-matched controls were enrolled in our study. Forearm blood flow was determined by gauge-strain plethysmography. Forearm vasodilatory response to reactive hyperemia was expressed as the %change from baseline to post-reactive hyperemia blood flow. High resolution ultrasound was used for determination of intima/media thickness and elastic properties of carotid and femoral arteries. Serum levels of soluble vascular adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), E-selectin, and interleukines 1b (IL-1b) and 6 (IL-6) were determined by ELISA. Reactive hyperemia was significantly decreased in patients compared to controls (p<0.01). Patients with SCR had higher intima/media thickness and decreased distensibility in the carotid arteries than controls (p<0.01 for both). Serum levels of sICAM-1, sSVCAM-1, E-selectin and IL-1b were higher in SCR group than in controls (p<0.05 for all). Adult patients after SCR have impaired endothelial function in the forearm circulation, increased intima/media thickness, decreased distensibility in the carotid arteries and increased levels of proinflammatory cytokines and adhesion molecules than healthy controls. These results may partly explain the high incidence of coronary artery disease in patients with repaired coarctation of the aorta.
Stella Brili; Dimitris Tousoulis; Charalambos Antoniades; Constantina Aggeli; Apostolos Roubelakis; Sotirios Papathanasiu; Christodoulos Stefanadis
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Publication Detail:
Type:  Journal Article     Date:  2005-02-24
Journal Detail:
Title:  Atherosclerosis     Volume:  182     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-23     Completed Date:  2006-01-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  97-103     Citation Subset:  IM    
Cardiology Unit, Hippokration Hospital, Athens University Medical School, Vasilissis Sofias 114, 11528 Athens, Greece.
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MeSH Terms
Age Factors
Aortic Coarctation / epidemiology,  physiopathology*,  surgery*
Carotid Arteries / physiopathology
Carotid Artery Diseases / epidemiology,  physiopathology*
Coronary Artery Disease / epidemiology,  physiopathology
E-Selectin / blood
Endothelium, Vascular / physiopathology
Femoral Artery / physiopathology
Interleukin-1 / blood
Postoperative Complications / epidemiology,  physiopathology
Regional Blood Flow
Vascular Cell Adhesion Molecule-1 / blood
Vasculitis / epidemiology,  physiopathology*
Reg. No./Substance:
0/E-Selectin; 0/Interleukin-1; 0/Vascular Cell Adhesion Molecule-1

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