| Evidence of unmetabolised folic acid in cord blood of newborn and serum of 4-day-old infants. | |
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MedLine Citation:
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PMID: 16277775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oral folic acid above certain threshold doses results in unmetabolised folic acid in serum. This raises a number of public health safety issues, principally the potential to mask pernicious anaemia; more recently the theoretical potential for high-dose folic acid to promote cancer has been highlighted. In this paper we set out to examine the appearance of unmetabolised folic acid both in cord blood from newborn full-term and premature infants and serum from 4-d-old infants post-formula feeding. Blood was collected from the umbilical cord of eleven infants in the delivery room immediately after birth. A follow-up serum sample (n 9) was collected 4 d later from infants post-formula feeding. We detected unmetabolised folic acid in cord blood from all infants at birth. In addition, unmetabolised folic acid was present in serum of seven infants post-formula feeding, six of which had increased from birth. Our results imply that infants in Ireland, which does not yet have mandatory fortification, could potentially have circulatory unmetabolised folic acid at the time of birth. We do not know if the presence of folic acid in cord blood will have any adverse consequences. However, if theoretical safety concerns are borne out by future research, the likelihood is that the longer the exposure the more likely the potential for harm. This would also be the case in infants exposed to unmetabolised folic acid as a result of formula feeding. |
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Authors:
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Mary R Sweeney; Joseph McPartlin; Donald G Weir; Sean Daly; Kristina Pentieva; Leslie Daly; John M Scott |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of nutrition Volume: 94 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-09 Completed Date: 2005-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 727-30 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine, University of Dublin, Trinity College, Dublin, Ireland. maryrose.sweeney@ucd.ie |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Fetal Blood
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metabolism* Folic Acid / blood*, metabolism Food, Fortified Humans Infant Formula Infant, Newborn Infant, Premature |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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