Document Detail

Evidence of unmetabolised folic acid in cord blood of newborn and serum of 4-day-old infants.
MedLine Citation:
PMID:  16277775     Owner:  NLM     Status:  MEDLINE    
Oral folic acid above certain threshold doses results in unmetabolised folic acid in serum. This raises a number of public health safety issues, principally the potential to mask pernicious anaemia; more recently the theoretical potential for high-dose folic acid to promote cancer has been highlighted. In this paper we set out to examine the appearance of unmetabolised folic acid both in cord blood from newborn full-term and premature infants and serum from 4-d-old infants post-formula feeding. Blood was collected from the umbilical cord of eleven infants in the delivery room immediately after birth. A follow-up serum sample (n 9) was collected 4 d later from infants post-formula feeding. We detected unmetabolised folic acid in cord blood from all infants at birth. In addition, unmetabolised folic acid was present in serum of seven infants post-formula feeding, six of which had increased from birth. Our results imply that infants in Ireland, which does not yet have mandatory fortification, could potentially have circulatory unmetabolised folic acid at the time of birth. We do not know if the presence of folic acid in cord blood will have any adverse consequences. However, if theoretical safety concerns are borne out by future research, the likelihood is that the longer the exposure the more likely the potential for harm. This would also be the case in infants exposed to unmetabolised folic acid as a result of formula feeding.
Mary R Sweeney; Joseph McPartlin; Donald G Weir; Sean Daly; Kristina Pentieva; Leslie Daly; John M Scott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  94     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-09     Completed Date:  2005-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  727-30     Citation Subset:  IM    
Department of Clinical Medicine, University of Dublin, Trinity College, Dublin, Ireland.
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MeSH Terms
Fetal Blood / metabolism*
Folic Acid / blood*,  metabolism
Food, Fortified
Infant Formula
Infant, Newborn
Infant, Premature
Reg. No./Substance:
59-30-3/Folic Acid

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