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Evidence of unexpected oxidative stress in airways of adolescents born very preterm.
MedLine Citation:
PMID:  22408207     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Prematurity and its main respiratory complication, bronchopulmonary dysplasia (BPD), are potentially associated with lifelong respiratory morbidities and/or lung function abnormalities. The mechanisms behind these long-term respiratory problems are still unclear.We assessed airway oxidative stress in adolescents born very preterm (≤ 32 gestational weeks) by measuring 8-isoprostane concentration in the exhaled breath condensate (EBC). In addition, the study protocol included spirometry and measuring nitric oxide in the exhaled air (FeNO).The study groups included 34 ex-preterm adolescents with BPD, 18 ex-preterm adolescents without BPD, and 34 healthy controls born at term.Regardless of a history of BPD, the ex-premature adolescents had higher EBC 8-isoprostane levels [BPD: 9.5(7.3-12.2); preterm non-BPD: 10(8.1-16) pg·mL(-1))] than the controls [3.2(1.9-6.5) pg·mL(-1)] (p<0.001). FEV1 was lower in the BPD group [Z-score:-2.1(1.58)] than in the preterm non-BPD individuals [-1.13(1.15)], who showed in turn significantly lower values than the controls [0.18(0.83); p<0.001]. FeNO was similar in the 3 groups (p=0.55).Our data show that, after premature birth, evidence of oxidative stress in the airways may be detected into adolescence, suggesting that long-term respiratory abnormalities after preterm birth may be associated with an ongoing airway disease and not just a stabilized structural lung damage.
Authors:
Marco Filippone; Gea Bonetto; Massimo Corradi; Anna Chiara Frigo; Eugenio Baraldi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-9
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Unit of Allergy and Respiratory Medicine - University of Padova, Padova, Italy.
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