| Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. | |
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MedLine Citation:
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PMID: 22411819 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct junction as a cancer cell of origin when a codon 12 K-Ras mutant is induced via adenoviral Cre inhalation. In the present study, we use two "knock-in" Cre-estrogen receptor alleles to inducibly express K-RasG12D in CC10(+) epithelial cells and Sftpc(+) type II alveolar cells of the adult mouse lung. Analysis of these mice identifies type II cells, Clara cells in the terminal bronchioles, and putative bronchoalveolar stem cells as cells of origin for K-Ras-induced lung hyperplasia. However, only type II cells appear to progress to adenocarcinoma. |
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Authors:
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Xia Xu; Jason R Rock; Yun Lu; Christopher Futtner; Brian Schwab; Justin Guinney; Brigid L M Hogan; Mark W Onaitis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-12 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: - ISSN: 1091-6490 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Surgery and Cell Biology, Duke University, Durham, NC 27710. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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