| Evidence of type 2 herpes simplex infection in human coronary arteries at the time of coronary artery bypass surgery. | |
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MedLine Citation:
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PMID: 8542544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine histologically biopsies from the coronary arteries of patients undergoing coronary artery bypass grafting (CABG) for evidence of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) antigen and to correlate the incidence with pathological and clinical data. DESIGN: Sequential patients undergoing CABG in whom adequate tissue could be obtained for histology. SETTING: University teaching hospital. PATIENTS: Forty-six patients were enrolled. Thirty-one provided sufficient tissue and clinical information for the analysis. METHODS: Biopsy material was collected in the operating room and prepared immediately for histology and electron microscopy. Slides were prepared by staining with hematoxylin and eosin, Masson trichrome, avidin biotin complex immunoperoxidase for HSV-1 and HSV-2 protein and specific DNA probes for HSV-1 and HSV-2 by hybridization. Clinical data were obtained in structured interviews. RESULTS: Sixty-one per cent of biopsies demonstrated evidence of inflammation, 45% were positive for antigen to HSV-2 and only one to HSV-1. Significant positive correlations were detected between inflammatory cells in the biopsy and a recent history of cold sores and between the presence of the infiltrate and positivity to HSV-2 antigen. CONCLUSION: A correlation exists between HSV-2 infection and the inflammatory response associated with atherosclerosis. |
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Authors:
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A Raza-Ahmad; G A Klassen; D A Murphy; J A Sullivan; C E Kinley; R W Landymore; J R Wood |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 11 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-02-12 Completed Date: 1996-02-12 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
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Languages: eng Pagination: 1025-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Victoria General Hospital, Halifax, Nova Scotia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, Viral / immunology Biopsy Coronary Artery Bypass* Coronary Disease / immunology, pathology, surgery, virology* Coronary Vessels / immunology, pathology, virology DNA Probes Female Herpes Simplex / immunology, virology* Herpesviridae Infections / immunology, pathology, surgery, virology* Herpesvirus 2, Human / immunology, isolation & purification* Humans Immunologic Tests Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Viral; 0/DNA Probes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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