Document Detail

Evidence for true obstruction to left ventricular outflow in obstructive hypertrophic cardiomyopathy (muscular or hypertrophic subaortic stenosis).
MedLine Citation:
PMID:  3433876     Owner:  NLM     Status:  MEDLINE    
In obstructive hypertrophic cardiomyopathy (muscular or hypertrophic subaortic stenosis), there is rapid early systolic ejection through an outflow tract that is narrowed by ventricular septal hypertrophy. This results in Venturi forces acting on the mitral leaflets, which cause mitral leaflet systolic anterior motion. Subsequent mitral leaflet-septal contact results in obstruction to left ventricular outflow and concomitant mitral regurgitation. Evidence is provided that the subaortic pressure gradient in obstructive hypertrophic cardiomyopathy reflects true obstruction to left ventricular outflow. It is important to distinguish this truly obstructive subaortic pressure gradient, due to mitral leaflet-septal contact, from an early systolic impulse gradient, as well as from the intraventricular pressure difference that may be encountered in midventricular obstruction or cavity obliteration.
E D Wigle; H Rakowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Kardiologie     Volume:  76 Suppl 3     ISSN:  0300-5860     ISO Abbreviation:  Z Kardiol     Publication Date:  1987  
Date Detail:
Created Date:  1988-03-21     Completed Date:  1988-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0360430     Medline TA:  Z Kardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
Department of Medicine, Toronto General Hospital, Canada.
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MeSH Terms
Aortic Valve Stenosis / physiopathology*
Blood Pressure
Cardiomyopathy, Hypertrophic / physiopathology*
Mitral Valve / physiopathology
Stroke Volume
Ventricular Outflow Obstruction*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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