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Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening.
MedLine Citation:
PMID:  22998193     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Parvovirus B19 (B19V) is a small, nonenveloped virus that typically causes a benign flu-like illness that occurs most frequently in childhood. The virus is resistant to current viral inactivation steps used in the manufacture of antihemophilic factor concentrates and B19V transmission through these products has been documented. Since 2000, B19V nucleic acid test (NAT) screening of plasma pools has been implemented to further decrease the viral burden in these products, but no study has examined populations using these products to assess the impact of the screening on B19V transmission. STUDY DESIGN AND METHODS: Blood specimens obtained from participants of a surveillance system established in federally supported specialized bleeding disorders clinics were used in a B19V seroprevalence study. RESULTS: A total of 1643 specimens from 1043 participants age 2 to 7 years born after B19V NAT screening was implemented were tested. Age-specific prevalence rates were generally higher for subjects exposed to either plasma-derived products alone or in combination with other products compared to subjects with no exposure to antihemophilic products. Overall, compared to participants unexposed to blood or blood products, those exposed to plasma-derived products alone were 1.7 times more likely to have antibodies to B19V (p = 0.002). CONCLUSION: These results are consistent with continued B19V transmission through plasma-derived factor concentrates. Effective viral inactivation and detection processes are needed to protect users of these products from infection with B19V or other new or emerging viruses.
Authors:
J Michael Soucie; Christine De Staercke; Paul E Monahan; Michael Recht; Meera B Chitlur; Ralph Gruppo; W Craig Hooper; Craig Kessler; Roshni Kulkarni; Marilyn J Manco-Johnson; Jerry Powell; Meredith Pyle; Brenda Riske; Hernan Sabio; Sean Trimble;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-24
Journal Detail:
Title:  Transfusion     Volume:  -     ISSN:  1537-2995     ISO Abbreviation:  Transfusion     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 American Association of Blood Banks.
Affiliation:
From the Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia; the University of North Carolina, Chapel Hill, North Carolina; the Oregon Health and Science University, Portland, Oregon; the Children's Hospital of Michigan, Detroit, Michigan; the Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; the Lombardi Cancer Center, Washington, DC; Michigan State University, East Lansing, Michigan; the University of Colorado School of Medicine, Aurora, Colorado; the University of California-Davis, Sacramento, California; and Wake Forest University, Winston-Salem, North Carolina.
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