Document Detail

Evidence that serotonin mediates some behavioral effects of amphetamine.
MedLine Citation:
PMID:  308099     Owner:  NLM     Status:  MEDLINE    
In the rat, d-amphetamine sulfate (15--80 mg/kg) causes numerous behavioral effects including simultaneous side-to-side head weaving or head tremor, forepaw padding and splayed hindlimbs. These signs are strikingly similar to a behavioral syndrome caused by intense serotonin (5-HT) receptor activation. Experiments were designed to determine whether some of the numerous effects of amphetamine on behavior can be ascribed to actions of the drug on 5-HT mechanisms. Catecholamine depletion with alpha-methyl-p-tyrosine did not prevent the amphetamine syndrome. However, 5-HT depletion with 5,7-dihydroxytryptamine or with p-chlorophenylalanine did prevent the syndrome. The degree of syndrome inhibition by p-chlorophenylalanine was correlated with the extent of 5-HT depletion. Normal responsiveness to amphetamine in p-chlorophenylalanine-treated rats was restored by 5-hydroxytryptophan, the precursor of 5-HT. Furthermore, methysergide, a 5-HT receptor blocker, prevented the amphetamine syndrome, whereas catecholamine blockers, phenoxybenzamine and pimozide, were ineffective. The results suggest that when amphetamine causes the signs of the syndrome it does so by activating 5-HT receptors in the brain, probably by displacement of endogenous 5-HT.
R S Sloviter; E G Drust; J D Connor
Related Documents :
2017509 - Neuroleptic malignant syndrome: occurrence in a child after reconstructive surgery.
9745819 - The hermansky-pudlak syndrome.
7593809 - Genitourinary tumors in men with the muir-torre syndrome.
11940929 - Electroconvulsive therapy in the neuroleptic malignant syndrome.
15508939 - Potentiation of haloperidol neurotoxicity in acute hyperthyroidism: report of a case.
6732389 - Neuroleptic malignant syndrome complicated by disseminated intravascular coagulation.
10922319 - Waterhouse-friderichsen syndrome and bilateral renal cortical necrosis in meningococcal...
22675019 - Ellis van creveld syndrome-a report of two siblings.
24010719 - Blau syndrome-associated uveitis and the nod2 gene.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  206     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  348-52     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
5,7-Dihydroxytryptamine / pharmacology
5-Hydroxytryptophan / pharmacology
Behavior, Animal / drug effects*
Brain Chemistry / drug effects
Dextroamphetamine / pharmacology*
Dopamine / analysis
Norepinephrine / analysis
Receptors, Serotonin / drug effects
Serotonin / analysis,  physiology*
Time Factors
Reg. No./Substance:
0/Receptors, Serotonin; 31363-74-3/5,7-Dihydroxytryptamine; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-64-9/Dextroamphetamine; 56-69-9/5-Hydroxytryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Determination of cerebrospinal fluid shunt function with water-soluble contrast medium.
Next Document:  Distribution of T-lymphocytes and B-lymphocytes in peripheral blood and effusions of patients with c...